The multifaceted role of macrophages during acute liver injury
The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-borne and gut-derived microbes and biological molecules, promoting tolerance of non-invasive antigens while driving immune responses against pathogenic ones. Liver resident immune cells such as Kupf...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237042/full |
| _version_ | 1797691146171842560 |
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| author | Ghada S. Hassan Manuel Flores Molina Manuel Flores Molina Naglaa H. Shoukry Naglaa H. Shoukry |
| author_facet | Ghada S. Hassan Manuel Flores Molina Manuel Flores Molina Naglaa H. Shoukry Naglaa H. Shoukry |
| author_sort | Ghada S. Hassan |
| collection | DOAJ |
| description | The liver is situated at the interface of the gut and circulation where it acts as a filter for blood-borne and gut-derived microbes and biological molecules, promoting tolerance of non-invasive antigens while driving immune responses against pathogenic ones. Liver resident immune cells such as Kupffer cells (KCs), a subset of macrophages, maintain homeostasis under physiological conditions. However, upon liver injury, these cells and others recruited from circulation participate in the response to injury and the repair of tissue damage. Such response is thus spatially and temporally regulated and implicates interconnected cells of immune and non-immune nature. This review will describe the hepatic immune environment during acute liver injury and the subsequent wound healing process. In its early stages, the wound healing immune response involves a necroinflammatory process characterized by partial depletion of resident KCs and lymphocytes and a significant infiltration of myeloid cells including monocyte-derived macrophages (MoMFs) complemented by a wave of pro-inflammatory mediators. The subsequent repair stage includes restoring KCs, initiating angiogenesis, renewing extracellular matrix and enhancing proliferation/activation of resident parenchymal and mesenchymal cells. This review will focus on the multifaceted role of hepatic macrophages, including KCs and MoMFs, and their spatial distribution and roles during acute liver injury. |
| first_indexed | 2024-03-12T02:10:06Z |
| format | Article |
| id | doaj.art-65ebd56d94f9462fa936bdf808758246 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T02:10:06Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-65ebd56d94f9462fa936bdf8087582462023-09-06T14:06:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12370421237042The multifaceted role of macrophages during acute liver injuryGhada S. Hassan0Manuel Flores Molina1Manuel Flores Molina2Naglaa H. Shoukry3Naglaa H. Shoukry4Centre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CanadaCentre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CanadaDépartement de microbiologie, infectiologie et immunologie, Faculté de médecine, Université de Montréal, Montréal, QC, CanadaCentre de Recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montréal, QC, CanadaDépartement de médecine, Faculté de médecine, Université de Montréal, Montréal, QC, CanadaThe liver is situated at the interface of the gut and circulation where it acts as a filter for blood-borne and gut-derived microbes and biological molecules, promoting tolerance of non-invasive antigens while driving immune responses against pathogenic ones. Liver resident immune cells such as Kupffer cells (KCs), a subset of macrophages, maintain homeostasis under physiological conditions. However, upon liver injury, these cells and others recruited from circulation participate in the response to injury and the repair of tissue damage. Such response is thus spatially and temporally regulated and implicates interconnected cells of immune and non-immune nature. This review will describe the hepatic immune environment during acute liver injury and the subsequent wound healing process. In its early stages, the wound healing immune response involves a necroinflammatory process characterized by partial depletion of resident KCs and lymphocytes and a significant infiltration of myeloid cells including monocyte-derived macrophages (MoMFs) complemented by a wave of pro-inflammatory mediators. The subsequent repair stage includes restoring KCs, initiating angiogenesis, renewing extracellular matrix and enhancing proliferation/activation of resident parenchymal and mesenchymal cells. This review will focus on the multifaceted role of hepatic macrophages, including KCs and MoMFs, and their spatial distribution and roles during acute liver injury.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237042/fulllivermacrophagesacute injurywound healing responsenecroinflammationtissue repair |
| spellingShingle | Ghada S. Hassan Manuel Flores Molina Manuel Flores Molina Naglaa H. Shoukry Naglaa H. Shoukry The multifaceted role of macrophages during acute liver injury Frontiers in Immunology liver macrophages acute injury wound healing response necroinflammation tissue repair |
| title | The multifaceted role of macrophages during acute liver injury |
| title_full | The multifaceted role of macrophages during acute liver injury |
| title_fullStr | The multifaceted role of macrophages during acute liver injury |
| title_full_unstemmed | The multifaceted role of macrophages during acute liver injury |
| title_short | The multifaceted role of macrophages during acute liver injury |
| title_sort | multifaceted role of macrophages during acute liver injury |
| topic | liver macrophages acute injury wound healing response necroinflammation tissue repair |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237042/full |
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