Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center
IntroductionDiverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.MethodsAdult patients with DD diagn...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1363548/full |
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| author | Giovanni Santacroce Giovanni Santacroce Marco Vincenzo Lenti Marco Vincenzo Lenti Giulia Maria Abruzzese Giulia Maria Abruzzese Giacomo Alunno Giacomo Alunno Francesco Di Terlizzi Francesco Di Terlizzi Carmine Frenna Carmine Frenna Antonella Gentile Antonella Gentile Mario Andrea Latorre Mario Andrea Latorre Clarissa Petrucci Clarissa Petrucci Damiano Ruggeri Damiano Ruggeri Simone Soriano Simone Soriano Nicola Aronico Annalisa De Silvestri Gino Roberto Corazza Gino Roberto Corazza Marietta Iacucci Antonio Di Sabatino Antonio Di Sabatino |
| author_facet | Giovanni Santacroce Giovanni Santacroce Marco Vincenzo Lenti Marco Vincenzo Lenti Giulia Maria Abruzzese Giulia Maria Abruzzese Giacomo Alunno Giacomo Alunno Francesco Di Terlizzi Francesco Di Terlizzi Carmine Frenna Carmine Frenna Antonella Gentile Antonella Gentile Mario Andrea Latorre Mario Andrea Latorre Clarissa Petrucci Clarissa Petrucci Damiano Ruggeri Damiano Ruggeri Simone Soriano Simone Soriano Nicola Aronico Annalisa De Silvestri Gino Roberto Corazza Gino Roberto Corazza Marietta Iacucci Antonio Di Sabatino Antonio Di Sabatino |
| author_sort | Giovanni Santacroce |
| collection | DOAJ |
| description | IntroductionDiverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.MethodsAdult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved. The patients were categorized as young or old based on the 25th percentile of the population's age at diagnosis. Univariate and multivariate analyses were performed to assess the association between the collected variables and the age of disease presentation. Additionally, survival analyses were conducted to evaluate the association between the age of diagnosis and clinical outcomes at follow-up, including disease recurrence, hospital access, surgery, and death.ResultsA total of 220 DD patients (with a median age of 66 years, IQR 55–74, and a female-to-male ratio of 1.4:1) were included in the study, comprising 54 patients receiving a diagnosis before the age of 49 years (young DD patients) and 166 patients diagnosed after the age of 49 years (old DD patients). Male sex (57 vs. 36%, p < 0.01), smoking (38 vs. 14%, p < 0.01), and alcohol consumption (54 vs. 38%) were highly prevalent in young patients. The complications at the time of diagnosis, particularly abscesses and free perforations, occurred more frequently in younger patients (p = 0.04). Moreover, young DD patients experienced a higher rate of hospitalization and surgical intervention (p = 0.01 and p = 0.04, respectively) over a median follow-up period of 5 years.ConclusionPreventive strategies and prompt diagnosis are crucial in young patients with DD for achieving better disease outcomes and preventing complications. |
| first_indexed | 2024-04-24T13:51:27Z |
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| id | doaj.art-65ec4027d6c54fe6818dc2b5b41925a2 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-24T13:51:27Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-65ec4027d6c54fe6818dc2b5b41925a22024-04-04T04:43:54ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-04-011110.3389/fmed.2024.13635481363548Clinical outcomes of diverticular disease in young adults: results from a tertiary referral centerGiovanni Santacroce0Giovanni Santacroce1Marco Vincenzo Lenti2Marco Vincenzo Lenti3Giulia Maria Abruzzese4Giulia Maria Abruzzese5Giacomo Alunno6Giacomo Alunno7Francesco Di Terlizzi8Francesco Di Terlizzi9Carmine Frenna10Carmine Frenna11Antonella Gentile12Antonella Gentile13Mario Andrea Latorre14Mario Andrea Latorre15Clarissa Petrucci16Clarissa Petrucci17Damiano Ruggeri18Damiano Ruggeri19Simone Soriano20Simone Soriano21Nicola Aronico22Annalisa De Silvestri23Gino Roberto Corazza24Gino Roberto Corazza25Marietta Iacucci26Antonio Di Sabatino27Antonio Di Sabatino28Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyScientific Direction, Clinical Epidemiology and Biometric Unit, San Matteo Hospital Foundation, Pavia, ItalyDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyAPC Microbiome Ireland, College of Medicine and Health, University College of Cork, Cork, IrelandDepartment of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, ItalyIntroductionDiverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.MethodsAdult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved. The patients were categorized as young or old based on the 25th percentile of the population's age at diagnosis. Univariate and multivariate analyses were performed to assess the association between the collected variables and the age of disease presentation. Additionally, survival analyses were conducted to evaluate the association between the age of diagnosis and clinical outcomes at follow-up, including disease recurrence, hospital access, surgery, and death.ResultsA total of 220 DD patients (with a median age of 66 years, IQR 55–74, and a female-to-male ratio of 1.4:1) were included in the study, comprising 54 patients receiving a diagnosis before the age of 49 years (young DD patients) and 166 patients diagnosed after the age of 49 years (old DD patients). Male sex (57 vs. 36%, p < 0.01), smoking (38 vs. 14%, p < 0.01), and alcohol consumption (54 vs. 38%) were highly prevalent in young patients. The complications at the time of diagnosis, particularly abscesses and free perforations, occurred more frequently in younger patients (p = 0.04). Moreover, young DD patients experienced a higher rate of hospitalization and surgical intervention (p = 0.01 and p = 0.04, respectively) over a median follow-up period of 5 years.ConclusionPreventive strategies and prompt diagnosis are crucial in young patients with DD for achieving better disease outcomes and preventing complications.https://www.frontiersin.org/articles/10.3389/fmed.2024.1363548/fulldiverticulahospitalizationoutcomepreventionrecurrencerisk factor |
| spellingShingle | Giovanni Santacroce Giovanni Santacroce Marco Vincenzo Lenti Marco Vincenzo Lenti Giulia Maria Abruzzese Giulia Maria Abruzzese Giacomo Alunno Giacomo Alunno Francesco Di Terlizzi Francesco Di Terlizzi Carmine Frenna Carmine Frenna Antonella Gentile Antonella Gentile Mario Andrea Latorre Mario Andrea Latorre Clarissa Petrucci Clarissa Petrucci Damiano Ruggeri Damiano Ruggeri Simone Soriano Simone Soriano Nicola Aronico Annalisa De Silvestri Gino Roberto Corazza Gino Roberto Corazza Marietta Iacucci Antonio Di Sabatino Antonio Di Sabatino Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center Frontiers in Medicine diverticula hospitalization outcome prevention recurrence risk factor |
| title | Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center |
| title_full | Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center |
| title_fullStr | Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center |
| title_full_unstemmed | Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center |
| title_short | Clinical outcomes of diverticular disease in young adults: results from a tertiary referral center |
| title_sort | clinical outcomes of diverticular disease in young adults results from a tertiary referral center |
| topic | diverticula hospitalization outcome prevention recurrence risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1363548/full |
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