Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies
Musalula Sinkala et al. report that collectively, specific mutations of genes in 5 MAPK pathways are associated with worse patient survival. They identify gene components that are pharmacologically vulnerable to pathway inhibitors in cancer cell models, suggesting potential clinical applications of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-020-01552-6 |
| _version_ | 1818690107089092608 |
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| author | Musalula Sinkala Panji Nkhoma Nicola Mulder Darren Patrick Martin |
| author_facet | Musalula Sinkala Panji Nkhoma Nicola Mulder Darren Patrick Martin |
| author_sort | Musalula Sinkala |
| collection | DOAJ |
| description | Musalula Sinkala et al. report that collectively, specific mutations of genes in 5 MAPK pathways are associated with worse patient survival. They identify gene components that are pharmacologically vulnerable to pathway inhibitors in cancer cell models, suggesting potential clinical applications of these findings. |
| first_indexed | 2024-12-17T12:20:44Z |
| format | Article |
| id | doaj.art-65ed10c9796044daa32dcf559a6c3a18 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-17T12:20:44Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-65ed10c9796044daa32dcf559a6c3a182022-12-21T21:48:58ZengNature PortfolioCommunications Biology2399-36422021-01-014111610.1038/s42003-020-01552-6Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependenciesMusalula Sinkala0Panji Nkhoma1Nicola Mulder2Darren Patrick Martin3University of Cape TownUniversity of ZambiaUniversity of Cape TownUniversity of Cape TownMusalula Sinkala et al. report that collectively, specific mutations of genes in 5 MAPK pathways are associated with worse patient survival. They identify gene components that are pharmacologically vulnerable to pathway inhibitors in cancer cell models, suggesting potential clinical applications of these findings.https://doi.org/10.1038/s42003-020-01552-6 |
| spellingShingle | Musalula Sinkala Panji Nkhoma Nicola Mulder Darren Patrick Martin Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies Communications Biology |
| title | Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| title_full | Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| title_fullStr | Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| title_full_unstemmed | Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| title_short | Integrated molecular characterisation of the MAPK pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| title_sort | integrated molecular characterisation of the mapk pathways in human cancers reveals pharmacologically vulnerable mutations and gene dependencies |
| url | https://doi.org/10.1038/s42003-020-01552-6 |
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