Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study
Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel form...
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MDPI AG
2018-01-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/10/1/15 |
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| author | Virginia Campani Eliana Pagnozzi Ilaria Mataro Laura Mayol Alessandra Perna Floriana D’Urso Antonietta Carillo Maria Cammarota Maria Chiara Maiuri Giuseppe De Rosa |
| author_facet | Virginia Campani Eliana Pagnozzi Ilaria Mataro Laura Mayol Alessandra Perna Floriana D’Urso Antonietta Carillo Maria Cammarota Maria Chiara Maiuri Giuseppe De Rosa |
| author_sort | Virginia Campani |
| collection | DOAJ |
| description | Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment. Thus, 20 adult volunteers with pressure ulcers within predetermined parameters were involved in a 30 days study. Dressing change was performed twice a week at outpatient clinic upon chronic wounds management. In the 90% of patients involved in the study, the treatment was effective, with a reduction of the area of the lesion and wound healing progress. The study demonstrated the efficacy of the gel formulation for treatment of pressure ulcers, also providing a strong reduction of patient management costs. |
| first_indexed | 2024-04-11T12:40:54Z |
| format | Article |
| id | doaj.art-65ee366780aa46ef97218e5b8d42d65d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T12:40:54Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-65ee366780aa46ef97218e5b8d42d65d2022-12-22T04:23:30ZengMDPI AGPharmaceutics1999-49232018-01-011011510.3390/pharmaceutics10010015pharmaceutics10010015Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot StudyVirginia Campani0Eliana Pagnozzi1Ilaria Mataro2Laura Mayol3Alessandra Perna4Floriana D’Urso5Antonietta Carillo6Maria Cammarota7Maria Chiara Maiuri8Giuseppe De Rosa9Department of Pharmacy, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Naples, ItalyM.D. Department of Plastic and Reconstructive Surgery and Burn Unit, Hospital Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, ItalyM.D. Department of Plastic and Reconstructive Surgery and Burn Unit, Hospital Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, ItalyDepartment of Pharmacy, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Naples, ItalyFirst Division of Nephrology, Department of Cardio-thoracic and Respiratory Sciences, Second University of Naples, School of Medicine, via Pansini 5, Ed. 17, 80131 Naples, ItalyU.O.S.C Farmacia, U.O.S.S. Galenica Clinica e Preparazione Farmaci Antiblastici, Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, ItalyU.O.S.C Farmacia, U.O.S.S. Galenica Clinica e Preparazione Farmaci Antiblastici, Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, ItalyU.O.S.C Farmacia, U.O.S.S. Galenica Clinica e Preparazione Farmaci Antiblastici, Hospital “A. Cardarelli”, Via A. Cardarelli 9, 80131 Naples, ItalyU.M.R.S. 1138, Centre de Recherche des Cordeliers, 15, rue de l’Ecole de Médecine, 75006 Paris, FranceDepartment of Pharmacy, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Naples, ItalyChitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment. Thus, 20 adult volunteers with pressure ulcers within predetermined parameters were involved in a 30 days study. Dressing change was performed twice a week at outpatient clinic upon chronic wounds management. In the 90% of patients involved in the study, the treatment was effective, with a reduction of the area of the lesion and wound healing progress. The study demonstrated the efficacy of the gel formulation for treatment of pressure ulcers, also providing a strong reduction of patient management costs.http://www.mdpi.com/1999-4923/10/1/15chitosangelpressure ulcerschronic woundswound healingclinical study |
| spellingShingle | Virginia Campani Eliana Pagnozzi Ilaria Mataro Laura Mayol Alessandra Perna Floriana D’Urso Antonietta Carillo Maria Cammarota Maria Chiara Maiuri Giuseppe De Rosa Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study Pharmaceutics chitosan gel pressure ulcers chronic wounds wound healing clinical study |
| title | Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study |
| title_full | Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study |
| title_fullStr | Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study |
| title_full_unstemmed | Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study |
| title_short | Chitosan Gel to Treat Pressure Ulcers: A Clinical Pilot Study |
| title_sort | chitosan gel to treat pressure ulcers a clinical pilot study |
| topic | chitosan gel pressure ulcers chronic wounds wound healing clinical study |
| url | http://www.mdpi.com/1999-4923/10/1/15 |
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