Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis
<i>Background and Objectives</i>: Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatment and hearing recovery. The ma...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/7/963 |
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| author | Andrea Frosolini Leonardo Franz Antonio Daloiso Andrea Lovato Cosimo de Filippis Gino Marioni |
| author_facet | Andrea Frosolini Leonardo Franz Antonio Daloiso Andrea Lovato Cosimo de Filippis Gino Marioni |
| author_sort | Andrea Frosolini |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatment and hearing recovery. The main aim of this systematic review and meta-analysis was to assess and critically discuss the role of circulating inflammatory biomarkers in SSNHL. <i>Materials and Methods</i>: A search was conducted of the English literature published between 1 January 2009 and 7 July 2022 on Pubmed, Scopus, Web of Science, ScienceDirect, and Cochrane following PRISMA guidelines. <i>Results</i>: A total of 256 titles were retrieved from the search. After full-text screening and application of inclusion/exclusion criteria, 13 articles were included. Twelve out of thirteen studies reported significant differences in biomarkers values in SSNHL patients, of which Tumor Necrosis Factor alpha (TNF-α) and C-reactive Protein (CRP) were the most analyzed. Our meta-analysis for CRP’s mean values in SSNHL groups vs. controls showed significantly higher CRP levels with a pooled overall difference of 1.07; confidence interval (CI) at 95%: 0.03; 2.11. For TNF-α, discordant results were found: three studies showed significantly higher levels in SSNHL patients vs. controls, whereas other three investigations showed lower levels in the SSNHL groups (overall pooled difference 1.97; 95% CI: −0.90; 4.84). A high between-study heterogeneity was found. <i>Conclusions</i>: This systematic review pointed out that, although there exists a growing literature in the field of circulatory biomarkers identification in SSNHL, there is a high heterogeneity of results and low quality of evidence. CRP resulted to be higher in SSNHL patients than in controls, while TNF-α showed more heterogeneous behavior. The data reported herein needs to be confirmed in well-designed prospective multicenter randomized studies, with the objective of improving SSNHL treatment and outcome and thereby reducing the social burden of hearing loss. |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T13:24:21Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-65eeb2f549ab4b43a08a52e1afbd10752023-11-30T21:25:36ZengMDPI AGMedicina1010-660X1648-91442022-07-0158796310.3390/medicina58070963Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-AnalysisAndrea Frosolini0Leonardo Franz1Antonio Daloiso2Andrea Lovato3Cosimo de Filippis4Gino Marioni5Department of Neuroscience DNS, Audiology Unit, University of Padova, 31100 Treviso, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, ItalyOtolaryngology Unit, Vicenza Hospital, 36100 Vicenza, ItalyDepartment of Neuroscience DNS, Audiology Unit, University of Padova, 31100 Treviso, ItalyDepartment of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy<i>Background and Objectives</i>: Sudden Sensorineural Hearing Loss (SSNHL) is a quite common clinical finding in otolaryngology. Most cases are classified as idiopathic and there is a dearth of information on factors able to predict the response to treatment and hearing recovery. The main aim of this systematic review and meta-analysis was to assess and critically discuss the role of circulating inflammatory biomarkers in SSNHL. <i>Materials and Methods</i>: A search was conducted of the English literature published between 1 January 2009 and 7 July 2022 on Pubmed, Scopus, Web of Science, ScienceDirect, and Cochrane following PRISMA guidelines. <i>Results</i>: A total of 256 titles were retrieved from the search. After full-text screening and application of inclusion/exclusion criteria, 13 articles were included. Twelve out of thirteen studies reported significant differences in biomarkers values in SSNHL patients, of which Tumor Necrosis Factor alpha (TNF-α) and C-reactive Protein (CRP) were the most analyzed. Our meta-analysis for CRP’s mean values in SSNHL groups vs. controls showed significantly higher CRP levels with a pooled overall difference of 1.07; confidence interval (CI) at 95%: 0.03; 2.11. For TNF-α, discordant results were found: three studies showed significantly higher levels in SSNHL patients vs. controls, whereas other three investigations showed lower levels in the SSNHL groups (overall pooled difference 1.97; 95% CI: −0.90; 4.84). A high between-study heterogeneity was found. <i>Conclusions</i>: This systematic review pointed out that, although there exists a growing literature in the field of circulatory biomarkers identification in SSNHL, there is a high heterogeneity of results and low quality of evidence. CRP resulted to be higher in SSNHL patients than in controls, while TNF-α showed more heterogeneous behavior. The data reported herein needs to be confirmed in well-designed prospective multicenter randomized studies, with the objective of improving SSNHL treatment and outcome and thereby reducing the social burden of hearing loss.https://www.mdpi.com/1648-9144/58/7/963sudden sensorineural hearing loss (SSNHL)circulating biomarkerstumor necrosis factor alphaC-reactive proteinprognosis |
| spellingShingle | Andrea Frosolini Leonardo Franz Antonio Daloiso Andrea Lovato Cosimo de Filippis Gino Marioni Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis Medicina sudden sensorineural hearing loss (SSNHL) circulating biomarkers tumor necrosis factor alpha C-reactive protein prognosis |
| title | Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis |
| title_full | Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis |
| title_fullStr | Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis |
| title_short | Digging into the Role of Inflammatory Biomarkers in Sudden Sensorineural Hearing Loss Diagnosis and Prognosis: A Systematic Review and Meta-Analysis |
| title_sort | digging into the role of inflammatory biomarkers in sudden sensorineural hearing loss diagnosis and prognosis a systematic review and meta analysis |
| topic | sudden sensorineural hearing loss (SSNHL) circulating biomarkers tumor necrosis factor alpha C-reactive protein prognosis |
| url | https://www.mdpi.com/1648-9144/58/7/963 |
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