Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.
<h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based c...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0041302 |
| _version_ | 1818736803456221184 |
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| author | Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group |
| author_facet | Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group |
| author_sort | Cornelia G de Waal |
| collection | DOAJ |
| description | <h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based cohort study of all infants born at 23 to 27 weeks of gestation in The Netherlands in 2007. 276 of 345 (80%) infants were born alive. Early neonatal death occurred in 96 (34.8%) live born infants, including 61 cases of delivery room death. 29 (10.5%) infants died during the late neonatal period. Survival rates for live born infants at 23, 24, 25 and 26 weeks of gestation were 0%, 6.7%, 57.9% and 71% respectively. 43.1% of 144 surviving infants developed severe neonatal morbidity (retinopathy of prematurity grade ≥3, bronchopulmonary dysplasia and/or severe brain injury). At two years of age 70.6% of the children had no disability, 17.6% was mild disabled and 11.8% had a moderate-to-severe disability. Severe brain injury (p = 0.028), retinopathy of prematurity grade ≥3 (p = 0.024), low gestational age (p = 0.019) and non-Dutch nationality of the mother (p = 0.004) increased the risk of disability.<h4>Conclusions/significance</h4>52% of extremely preterm infants born in The Netherlands in 2007 survived. Surviving infants had less severe neonatal morbidity compared to previous studies. At two years of age less than 30% of the infants were disabled. Disability was associated with gestational age and neonatal morbidity. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T00:42:57Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-65eede30ebdf463facc74fd6a10e611b2022-12-21T21:26:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4130210.1371/journal.pone.0041302Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007.Cornelia G de WaalNynke Weisglas-KuperusJohannes B van GoudoeverFrans J WaltherNeoNed Study GroupLNF Study Group<h4>Background</h4>Extremely preterm infants are at high risk of neonatal mortality and adverse outcome. Survival rates are slowly improving, but increased survival may come at the expense of more handicaps.<h4>Methodology/principal findings</h4>Prospective population-based cohort study of all infants born at 23 to 27 weeks of gestation in The Netherlands in 2007. 276 of 345 (80%) infants were born alive. Early neonatal death occurred in 96 (34.8%) live born infants, including 61 cases of delivery room death. 29 (10.5%) infants died during the late neonatal period. Survival rates for live born infants at 23, 24, 25 and 26 weeks of gestation were 0%, 6.7%, 57.9% and 71% respectively. 43.1% of 144 surviving infants developed severe neonatal morbidity (retinopathy of prematurity grade ≥3, bronchopulmonary dysplasia and/or severe brain injury). At two years of age 70.6% of the children had no disability, 17.6% was mild disabled and 11.8% had a moderate-to-severe disability. Severe brain injury (p = 0.028), retinopathy of prematurity grade ≥3 (p = 0.024), low gestational age (p = 0.019) and non-Dutch nationality of the mother (p = 0.004) increased the risk of disability.<h4>Conclusions/significance</h4>52% of extremely preterm infants born in The Netherlands in 2007 survived. Surviving infants had less severe neonatal morbidity compared to previous studies. At two years of age less than 30% of the infants were disabled. Disability was associated with gestational age and neonatal morbidity.https://doi.org/10.1371/journal.pone.0041302 |
| spellingShingle | Cornelia G de Waal Nynke Weisglas-Kuperus Johannes B van Goudoever Frans J Walther NeoNed Study Group LNF Study Group Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. PLoS ONE |
| title | Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. |
| title_full | Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. |
| title_fullStr | Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. |
| title_full_unstemmed | Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. |
| title_short | Mortality, neonatal morbidity and two year follow-up of extremely preterm infants born in The Netherlands in 2007. |
| title_sort | mortality neonatal morbidity and two year follow up of extremely preterm infants born in the netherlands in 2007 |
| url | https://doi.org/10.1371/journal.pone.0041302 |
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