Melanocytes in regenerative medicine applications and disease modeling
Abstract Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible for skin, eye and hair pigmentation. They also have different functions in photopr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05113-x |
| _version_ | 1797209060550901760 |
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| author | Kelly Coutant Brice Magne Karel Ferland Aurélie Fuentes-Rodriguez Olivier Chancy Andrew Mitchell Lucie Germain Solange Landreville |
| author_facet | Kelly Coutant Brice Magne Karel Ferland Aurélie Fuentes-Rodriguez Olivier Chancy Andrew Mitchell Lucie Germain Solange Landreville |
| author_sort | Kelly Coutant |
| collection | DOAJ |
| description | Abstract Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible for skin, eye and hair pigmentation. They also have different functions in photoprotection, immunity and sound perception. Melanocyte dysfunction can cause pigmentary disorders, hearing and vision impairments or increased cancer susceptibility. This review focuses on the role of melanocytes in homeostasis and disease, before discussing their potential in regenerative medicine applications, such as for disease modeling, drug testing or therapy development using stem cell technologies, tissue engineering and extracellular vesicles. |
| first_indexed | 2024-04-24T09:48:42Z |
| format | Article |
| id | doaj.art-65ef924c40504b6d8a03573e85098657 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-24T09:48:42Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-65ef924c40504b6d8a03573e850986572024-04-14T11:27:41ZengBMCJournal of Translational Medicine1479-58762024-04-0122111810.1186/s12967-024-05113-xMelanocytes in regenerative medicine applications and disease modelingKelly Coutant0Brice Magne1Karel Ferland2Aurélie Fuentes-Rodriguez3Olivier Chancy4Andrew Mitchell5Lucie Germain6Solange Landreville7Department of Ophthalmology and Otorhinolaryngology-Cervico-Facial Surgery, Faculty of Medicine, Université LavalRegenerative Medicine Division, CHU de Québec-Université Laval Research CentreRegenerative Medicine Division, CHU de Québec-Université Laval Research CentreDepartment of Ophthalmology and Otorhinolaryngology-Cervico-Facial Surgery, Faculty of Medicine, Université LavalDepartment of Ophthalmology and Otorhinolaryngology-Cervico-Facial Surgery, Faculty of Medicine, Université LavalDepartment of Ophthalmology and Otorhinolaryngology-Cervico-Facial Surgery, Faculty of Medicine, Université LavalRegenerative Medicine Division, CHU de Québec-Université Laval Research CentreDepartment of Ophthalmology and Otorhinolaryngology-Cervico-Facial Surgery, Faculty of Medicine, Université LavalAbstract Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible for skin, eye and hair pigmentation. They also have different functions in photoprotection, immunity and sound perception. Melanocyte dysfunction can cause pigmentary disorders, hearing and vision impairments or increased cancer susceptibility. This review focuses on the role of melanocytes in homeostasis and disease, before discussing their potential in regenerative medicine applications, such as for disease modeling, drug testing or therapy development using stem cell technologies, tissue engineering and extracellular vesicles.https://doi.org/10.1186/s12967-024-05113-xMelanocytesRegenerative medicineSpheroidTissue engineeringExtracellular vesiclesStem cells |
| spellingShingle | Kelly Coutant Brice Magne Karel Ferland Aurélie Fuentes-Rodriguez Olivier Chancy Andrew Mitchell Lucie Germain Solange Landreville Melanocytes in regenerative medicine applications and disease modeling Journal of Translational Medicine Melanocytes Regenerative medicine Spheroid Tissue engineering Extracellular vesicles Stem cells |
| title | Melanocytes in regenerative medicine applications and disease modeling |
| title_full | Melanocytes in regenerative medicine applications and disease modeling |
| title_fullStr | Melanocytes in regenerative medicine applications and disease modeling |
| title_full_unstemmed | Melanocytes in regenerative medicine applications and disease modeling |
| title_short | Melanocytes in regenerative medicine applications and disease modeling |
| title_sort | melanocytes in regenerative medicine applications and disease modeling |
| topic | Melanocytes Regenerative medicine Spheroid Tissue engineering Extracellular vesicles Stem cells |
| url | https://doi.org/10.1186/s12967-024-05113-x |
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