ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock
While previous reports showed ADP-induced platelet reactivity to be an independent predictor of bleeding after PCI in stable patients, this has never been investigated in patients with cardiogenic shock. The association of bleeding events with respect to ADP-induced platelet aggregation was investig...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-04-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2021.1913577 |
| _version_ | 1797684136144535552 |
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| author | Clemens Scherer Enzo Lüsebrink Danny Kupka Thomas J. Stocker Konstantin Stark Jan Kleeberger Mathias Orban Antonia Kellnar Tobias Petzold Simon Deseive Kathrin Krieg Sara Würbel Sara Kika Mario Istrefi Stefan Brunner Daniel Braun Christian Hagl Jörg Hausleiter Steffen Massberg Dirk Sibbing Martin Orban |
| author_facet | Clemens Scherer Enzo Lüsebrink Danny Kupka Thomas J. Stocker Konstantin Stark Jan Kleeberger Mathias Orban Antonia Kellnar Tobias Petzold Simon Deseive Kathrin Krieg Sara Würbel Sara Kika Mario Istrefi Stefan Brunner Daniel Braun Christian Hagl Jörg Hausleiter Steffen Massberg Dirk Sibbing Martin Orban |
| author_sort | Clemens Scherer |
| collection | DOAJ |
| description | While previous reports showed ADP-induced platelet reactivity to be an independent predictor of bleeding after PCI in stable patients, this has never been investigated in patients with cardiogenic shock. The association of bleeding events with respect to ADP-induced platelet aggregation was investigated in patients undergoing primary PCI for acute myocardial infarction complicated by cardiogenic shock and with available on-treatment ADP-induced platelet aggregation measurements. Out of 233 patients, 74 suffered from a severe BARC3 or higher bleed. ADP-induced platelet aggregation was significantly lower in patients with BARC≥3 bleedings (p < .001). Multivariate analysis identified on-treatment ADP-induced platelet aggregation as an independent risk factor for bleeding (HR = 0.968 per AU). An optimal cutoff value of <12 AU for ADP-induced platelet aggregation to predict BARC≥3 bleedings was identified via ROC analysis. Moreover, the use of VA-ECMO (HR 1.972) or coaxial left ventricular pump (HR 2.593), first lactate (HR 1.093 per mmol/l) and thrombocyte count (HR 0.994 per G/l) were independent predictors of BARC≥3 bleedings. In conclusion, lower on-treatment ADP-induced platelet aggregation was independently associated with severe bleeding events in patients with AMI-CS. The value of platelet function testing for bleeding risk prediction and guidance of anti-thrombotic treatment in cardiogenic shock warrants further investigation. |
| first_indexed | 2024-03-12T00:25:08Z |
| format | Article |
| id | doaj.art-65f1def0ad5444528943948ee079365a |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:08Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-65f1def0ad5444528943948ee079365a2023-09-15T10:38:09ZengTaylor & Francis GroupPlatelets0953-71041369-16352022-04-0133337138010.1080/09537104.2021.19135771913577ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shockClemens Scherer0Enzo Lüsebrink1Danny Kupka2Thomas J. Stocker3Konstantin Stark4Jan Kleeberger5Mathias Orban6Antonia Kellnar7Tobias Petzold8Simon Deseive9Kathrin Krieg10Sara Würbel11Sara Kika12Mario Istrefi13Stefan Brunner14Daniel Braun15Christian Hagl16Jörg Hausleiter17Steffen Massberg18Dirk Sibbing19Martin Orban20University Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichUniversity Hospital, LMU MunichWhile previous reports showed ADP-induced platelet reactivity to be an independent predictor of bleeding after PCI in stable patients, this has never been investigated in patients with cardiogenic shock. The association of bleeding events with respect to ADP-induced platelet aggregation was investigated in patients undergoing primary PCI for acute myocardial infarction complicated by cardiogenic shock and with available on-treatment ADP-induced platelet aggregation measurements. Out of 233 patients, 74 suffered from a severe BARC3 or higher bleed. ADP-induced platelet aggregation was significantly lower in patients with BARC≥3 bleedings (p < .001). Multivariate analysis identified on-treatment ADP-induced platelet aggregation as an independent risk factor for bleeding (HR = 0.968 per AU). An optimal cutoff value of <12 AU for ADP-induced platelet aggregation to predict BARC≥3 bleedings was identified via ROC analysis. Moreover, the use of VA-ECMO (HR 1.972) or coaxial left ventricular pump (HR 2.593), first lactate (HR 1.093 per mmol/l) and thrombocyte count (HR 0.994 per G/l) were independent predictors of BARC≥3 bleedings. In conclusion, lower on-treatment ADP-induced platelet aggregation was independently associated with severe bleeding events in patients with AMI-CS. The value of platelet function testing for bleeding risk prediction and guidance of anti-thrombotic treatment in cardiogenic shock warrants further investigation.http://dx.doi.org/10.1080/09537104.2021.1913577platelet reactivitycardiogenic shockbleedingacute myocardial infarctionva-ecmoimpella |
| spellingShingle | Clemens Scherer Enzo Lüsebrink Danny Kupka Thomas J. Stocker Konstantin Stark Jan Kleeberger Mathias Orban Antonia Kellnar Tobias Petzold Simon Deseive Kathrin Krieg Sara Würbel Sara Kika Mario Istrefi Stefan Brunner Daniel Braun Christian Hagl Jörg Hausleiter Steffen Massberg Dirk Sibbing Martin Orban ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock Platelets platelet reactivity cardiogenic shock bleeding acute myocardial infarction va-ecmo impella |
| title | ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_full | ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_fullStr | ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_full_unstemmed | ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_short | ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| title_sort | adp induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock |
| topic | platelet reactivity cardiogenic shock bleeding acute myocardial infarction va-ecmo impella |
| url | http://dx.doi.org/10.1080/09537104.2021.1913577 |
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