Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium
In this study, the chemical composition of the essential oil of Teucrium scordium was studied using capillary GC and GC/MS instruments. In addition, the antimicrobial and cytotoxic activities of the oil and methanol extract were evaluated by disc diffusion and MTT assays, respectively. Forty-three v...
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| Format: | Article |
| Language: | English |
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Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR
2020-04-01
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| Series: | Iranian Journal of Chemistry & Chemical Engineering |
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| Online Access: | http://www.ijcce.ac.ir/article_36074_f69fe338e9270b3a3be00253be6a53ed.pdf |
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| author | Parisa Ebrahimi Fateme Aboee-Mehrizi Mahmood Dehghani Ashkezari Samaneh Sedighi Henghame Amirian |
| author_facet | Parisa Ebrahimi Fateme Aboee-Mehrizi Mahmood Dehghani Ashkezari Samaneh Sedighi Henghame Amirian |
| author_sort | Parisa Ebrahimi |
| collection | DOAJ |
| description | In this study, the chemical composition of the essential oil of Teucrium scordium was studied using capillary GC and GC/MS instruments. In addition, the antimicrobial and cytotoxic activities of the oil and methanol extract were evaluated by disc diffusion and MTT assays, respectively. Forty-three volatile components were identified from the oil of aerial parts, representing of 98.1% of total oil. The major constituents were trans-α-bergamotene (52.3%), (Z)-α-trans-bergamotol (18.1%), linalool (3.0%) and piperitenone oxide (2.9%). The best anti-bacterial activity was observed for the methanol extract against Staphylococcus epidermidis with ZI (19.0 ± 0.47) mm and also against Proteus mirabilis with MIC value of 1.25 µg/mL.Investigation of the samples on cell viability of HeLa cells showed good activity for the essential oil with an IC50 value of 5.2 µg/mL. Our results indicated that Teucrium scordium can be considered for further analyses as an effective and safe curing agent for cancer and pathogenic infection therapies. |
| first_indexed | 2024-12-18T10:25:34Z |
| format | Article |
| id | doaj.art-65f3f053146b4d0090d086ca407b51e7 |
| institution | Directory Open Access Journal |
| issn | 1021-9986 1021-9986 |
| language | English |
| last_indexed | 2024-12-18T10:25:34Z |
| publishDate | 2020-04-01 |
| publisher | Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR |
| record_format | Article |
| series | Iranian Journal of Chemistry & Chemical Engineering |
| spelling | doaj.art-65f3f053146b4d0090d086ca407b51e72022-12-21T21:10:59ZengIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRIranian Journal of Chemistry & Chemical Engineering1021-99861021-99862020-04-0139220721510.30492/ijcce.2020.3607436074Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordiumParisa Ebrahimi0Fateme Aboee-Mehrizi1Mahmood Dehghani Ashkezari2Samaneh Sedighi3Henghame Amirian4Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRANDepartment of Medicine, Yazd Branch, Islamic Azad University, Yazd, I.R. IRANMedical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRANMedical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, I.R. IRANDepartment of Medicine, Yazd Branch, Islamic Azad University, Yazd, R. IRANIn this study, the chemical composition of the essential oil of Teucrium scordium was studied using capillary GC and GC/MS instruments. In addition, the antimicrobial and cytotoxic activities of the oil and methanol extract were evaluated by disc diffusion and MTT assays, respectively. Forty-three volatile components were identified from the oil of aerial parts, representing of 98.1% of total oil. The major constituents were trans-α-bergamotene (52.3%), (Z)-α-trans-bergamotol (18.1%), linalool (3.0%) and piperitenone oxide (2.9%). The best anti-bacterial activity was observed for the methanol extract against Staphylococcus epidermidis with ZI (19.0 ± 0.47) mm and also against Proteus mirabilis with MIC value of 1.25 µg/mL.Investigation of the samples on cell viability of HeLa cells showed good activity for the essential oil with an IC50 value of 5.2 µg/mL. Our results indicated that Teucrium scordium can be considered for further analyses as an effective and safe curing agent for cancer and pathogenic infection therapies.http://www.ijcce.ac.ir/article_36074_f69fe338e9270b3a3be00253be6a53ed.pdfteucrium scordiumessential oilantimicrobial activitycell viability |
| spellingShingle | Parisa Ebrahimi Fateme Aboee-Mehrizi Mahmood Dehghani Ashkezari Samaneh Sedighi Henghame Amirian Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium Iranian Journal of Chemistry & Chemical Engineering teucrium scordium essential oil antimicrobial activity cell viability |
| title | Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium |
| title_full | Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium |
| title_fullStr | Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium |
| title_full_unstemmed | Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium |
| title_short | Chemical Composition and Biological Activities of Essential Oil and Methanol Extract of Teucrium scordium |
| title_sort | chemical composition and biological activities of essential oil and methanol extract of teucrium scordium |
| topic | teucrium scordium essential oil antimicrobial activity cell viability |
| url | http://www.ijcce.ac.ir/article_36074_f69fe338e9270b3a3be00253be6a53ed.pdf |
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