Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
Suppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20674-3 |
| _version_ | 1818429224879390720 |
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| author | Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao |
| author_facet | Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao |
| author_sort | Xin Chen |
| collection | DOAJ |
| description | Suppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression. |
| first_indexed | 2024-12-14T15:14:07Z |
| format | Article |
| id | doaj.art-65f40b92b773475c8ead94676c9fa129 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:14:07Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-65f40b92b773475c8ead94676c9fa1292022-12-21T22:56:25ZengNature PortfolioNature Communications2041-17232021-01-0112111510.1038/s41467-020-20674-3Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaborationXin Chen0Sarah M. Lloyd1Junghun Kweon2Giovanni M. Gamalong3Xiaomin Bao4Department of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern UniversityDepartment of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern UniversityDepartment of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern UniversityDepartment of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern UniversityDepartment of Molecular Biosciences; Weinberg College of Arts and Sciences, Northwestern UniversitySuppression of terminal differentiation is essential for epidermal progenitor maintenance. Here, the authors show that intronic polyadenylation is dynamically regulated by the cooperation between CPSF and RNA-binding proteins to influence epidermal differentiation gene expression.https://doi.org/10.1038/s41467-020-20674-3 |
| spellingShingle | Xin Chen Sarah M. Lloyd Junghun Kweon Giovanni M. Gamalong Xiaomin Bao Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration Nature Communications |
| title | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration |
| title_full | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration |
| title_fullStr | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration |
| title_full_unstemmed | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration |
| title_short | Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration |
| title_sort | epidermal progenitors suppress grhl3 mediated differentiation through intronic polyadenylation promoted by cpsf hnrnpa3 collaboration |
| url | https://doi.org/10.1038/s41467-020-20674-3 |
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