Effect of photodynamic doses of laser irradiation on endogenous intoxication indices
Background: One of the promising areas in ophthalmology is photodynamic therapy (PDT). Purpose: To assess the effect of laser irradiation of the rat eye at the doses applied in PDT (without photosensitizer) on endogenous intoxication indices. Materials and Methods: Fifty rats were used to inve...
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2015-07-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2015/4/6-fulltext |
| _version_ | 1797354153399287808 |
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| author | F.A. Bakhritdinova K.I. Narzikulova S.Sh. Mirrakhimova |
| author_facet | F.A. Bakhritdinova K.I. Narzikulova S.Sh. Mirrakhimova |
| author_sort | F.A. Bakhritdinova |
| collection | DOAJ |
| description | Background: One of the promising areas in ophthalmology is photodynamic therapy (PDT).
Purpose: To assess the effect of laser irradiation of the rat eye at the doses applied in PDT (without photosensitizer) on endogenous intoxication indices.
Materials and Methods: Fifty rats were used to investigate the effect of different modes of photodynamic irradiation of the rat eye on changes in endogenous intoxication indices over time.
Results: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J photodynamic dose (PDD) mode (15 s) does not result in the development of endogenous intoxication. According to the literature, serum level of middle-weight molecules (MWM) is an integral marker of metabolic disorders of the body and can be used as evidence of the intensity of endogenous intoxication.
Conclusion: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J PDD mode (15 s) does not result in the development of endogenous intoxication, making possible the application of these modes in practical ophthalmology. Because exposure to 890-nm laser irradiation of 300-mJ pulsed mode (3 min), and, especially, to 630-nm laser irradiation of 120-J PDD mode (30 s) results in the increased accumulation of MWM in circulating blood of animals, the eye should not be exposed to such irradiation doses. |
| first_indexed | 2024-03-08T13:45:26Z |
| format | Article |
| id | doaj.art-65f4178c4eab4841a0d7fc845fb798dc |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-08T13:45:26Z |
| publishDate | 2015-07-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-65f4178c4eab4841a0d7fc845fb798dc2024-01-16T09:25:51ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402015-07-014353710.31288/oftalmolzh201543537Effect of photodynamic doses of laser irradiation on endogenous intoxication indicesF.A. Bakhritdinova0K.I. Narzikulova1S.Sh. Mirrakhimova2Tashkent Medical AcademyTashkent Medical AcademyTashkent Medical AcademyBackground: One of the promising areas in ophthalmology is photodynamic therapy (PDT). Purpose: To assess the effect of laser irradiation of the rat eye at the doses applied in PDT (without photosensitizer) on endogenous intoxication indices. Materials and Methods: Fifty rats were used to investigate the effect of different modes of photodynamic irradiation of the rat eye on changes in endogenous intoxication indices over time. Results: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J photodynamic dose (PDD) mode (15 s) does not result in the development of endogenous intoxication. According to the literature, serum level of middle-weight molecules (MWM) is an integral marker of metabolic disorders of the body and can be used as evidence of the intensity of endogenous intoxication. Conclusion: Exposure to 630-nm laser irradiation of 300-mJ pulsed mode (3 min) and 60-J PDD mode (15 s) does not result in the development of endogenous intoxication, making possible the application of these modes in practical ophthalmology. Because exposure to 890-nm laser irradiation of 300-mJ pulsed mode (3 min), and, especially, to 630-nm laser irradiation of 120-J PDD mode (30 s) results in the increased accumulation of MWM in circulating blood of animals, the eye should not be exposed to such irradiation doses.https://www.ozhurnal.com/en/archive/2015/4/6-fulltextphotodynamic therapyendogenous intoxicationmiddle-weight molecules (mwm) |
| spellingShingle | F.A. Bakhritdinova K.I. Narzikulova S.Sh. Mirrakhimova Effect of photodynamic doses of laser irradiation on endogenous intoxication indices Journal of Ophthalmology photodynamic therapy endogenous intoxication middle-weight molecules (mwm) |
| title | Effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| title_full | Effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| title_fullStr | Effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| title_full_unstemmed | Effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| title_short | Effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| title_sort | effect of photodynamic doses of laser irradiation on endogenous intoxication indices |
| topic | photodynamic therapy endogenous intoxication middle-weight molecules (mwm) |
| url | https://www.ozhurnal.com/en/archive/2015/4/6-fulltext |
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