Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region

Mycobacterium tuberculosis has been observed to develop resistance to the frontline anti-tuberculosis drug rifampicin, primarily through mutations in the rifampicin resistance-determining region (RRDR) of rpoB. While these mutations have been determined to confer a fitness cost, compensatory mutatio...

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Bibliographic Details
Main Authors: Pengjiao Ma, Tao Luo, Liang Ge, Zonghai Chen, Xinyan Wang, Rongchuan Zhao, Wei Liao, Lang Bao
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Emerging Microbes and Infections
Subjects:
M. tuberculosis
rifampicin resistance
rpoB mutation
fitness cost
fitness compensation
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2021.1908096

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