Significance of exosomes in hepatocellular carcinoma
Among the most prevalent cancers in the world, hepatocellular carcinoma (HCC) has a high mortality rate. The diagnosis and management of HCC are presently hindered by difficulties in early detection and suboptimal treatment outcomes. Exosomes have been shown to play an important role in hepatocarcin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1056379/full |
| _version_ | 1811321095284850688 |
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| author | GuoYun Wang GaiXiang Luo MeiJing Zhao HuiLai Miao HuiLai Miao |
| author_facet | GuoYun Wang GaiXiang Luo MeiJing Zhao HuiLai Miao HuiLai Miao |
| author_sort | GuoYun Wang |
| collection | DOAJ |
| description | Among the most prevalent cancers in the world, hepatocellular carcinoma (HCC) has a high mortality rate. The diagnosis and management of HCC are presently hindered by difficulties in early detection and suboptimal treatment outcomes. Exosomes have been shown to play an important role in hepatocarcinogenesis and can also be used for diagnosis and treatment. In this review, we discussed the research progress on exosomes in hepatocarcinogenesis development, tumor microenvironment remodeling, treatment resistance, and immunosuppression. HCC can be diagnosed and treated by understanding the pathogenesis and identifying early diagnostic markers. This review will be a significant reference for scholars with an initial understanding of the field to fully understand the role of exosomes in the organism. |
| first_indexed | 2024-04-13T13:10:44Z |
| format | Article |
| id | doaj.art-65f7459e9f814079b4360c9765cb879c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T13:10:44Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-65f7459e9f814079b4360c9765cb879c2022-12-22T02:45:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10563791056379Significance of exosomes in hepatocellular carcinomaGuoYun Wang0GaiXiang Luo1MeiJing Zhao2HuiLai Miao3HuiLai Miao4Department of Hepatobiliary Surgery, The Second Hospital of Guangdong Medical University, Zhanjiang, ChinaThe First Clinical Medical College of Lanzhou University, Gansu Provincial People’s Hospital, Lanzhou, ChinaDepartment of Hepatobiliary Surgery, The Second Hospital of Guangdong Medical University, Zhanjiang, ChinaDepartment of Hepatobiliary Surgery, The Second Hospital of Guangdong Medical University, Zhanjiang, ChinaKey Laboratory of Liver Injury Diagnosis and Repair, Guangdong Medical University, Zhanjiang, ChinaAmong the most prevalent cancers in the world, hepatocellular carcinoma (HCC) has a high mortality rate. The diagnosis and management of HCC are presently hindered by difficulties in early detection and suboptimal treatment outcomes. Exosomes have been shown to play an important role in hepatocarcinogenesis and can also be used for diagnosis and treatment. In this review, we discussed the research progress on exosomes in hepatocarcinogenesis development, tumor microenvironment remodeling, treatment resistance, and immunosuppression. HCC can be diagnosed and treated by understanding the pathogenesis and identifying early diagnostic markers. This review will be a significant reference for scholars with an initial understanding of the field to fully understand the role of exosomes in the organism.https://www.frontiersin.org/articles/10.3389/fonc.2022.1056379/fullexosomeshepatocellular carcinomamicroenvironmentdrug resistancedevelopmenttreatments |
| spellingShingle | GuoYun Wang GaiXiang Luo MeiJing Zhao HuiLai Miao HuiLai Miao Significance of exosomes in hepatocellular carcinoma Frontiers in Oncology exosomes hepatocellular carcinoma microenvironment drug resistance development treatments |
| title | Significance of exosomes in hepatocellular carcinoma |
| title_full | Significance of exosomes in hepatocellular carcinoma |
| title_fullStr | Significance of exosomes in hepatocellular carcinoma |
| title_full_unstemmed | Significance of exosomes in hepatocellular carcinoma |
| title_short | Significance of exosomes in hepatocellular carcinoma |
| title_sort | significance of exosomes in hepatocellular carcinoma |
| topic | exosomes hepatocellular carcinoma microenvironment drug resistance development treatments |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1056379/full |
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