Quiescent Elongation of α-Synuclein Pre-form Fibrils Under Different Solution Conditions

Quiescent Elongation of α-Synuclein Pre-form Fibrils Under Different Solution Conditions

The intracellular aggregation of α-synuclein in neurons/glia is considered to be a key step in the pathogenesis of synucleinopathy [including Parkinson’s disease (PD), dementia with Lewy body (DLB), multiple system atrophy (MSA), etc.]. Increasing evidence indicates that the initial pathological α-s...

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Bibliographic Details
Main Authors: Hengxu Mao, Yongyi Ye, Xiang Sun, Chen Qian, Baoyan Wang, Linghai Xie, Shizhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
α-synuclein
aggregates
PFFs
PD
fibrillation
synucleinopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.902077/full

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