Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis
Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein phosphatases catalyze dephosphorylation of thousands...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/814 |
| _version_ | 1827841736102117376 |
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| author | Meghna Kataria Hiroyuki Yamano |
| author_facet | Meghna Kataria Hiroyuki Yamano |
| author_sort | Meghna Kataria |
| collection | DOAJ |
| description | Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic phase and exit from it. A large E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) becomes active during latter stages of mitosis through G1 and marks hundreds of proteins for destruction. Recent studies have revealed the complex interregulation between these two classes of enzymes. In this review, we highlight the direct and indirect mechanisms by which phosphatases and the APC/C mutually influence each other to ensure accurate spatiotemporal and orderly progression through mitosis, with a particular focus on recent insights and conceptual advances. |
| first_indexed | 2024-03-12T07:56:51Z |
| format | Article |
| id | doaj.art-65f7f3a5e8be4a00b4ffa656c8dbf944 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:56:51Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-65f7f3a5e8be4a00b4ffa656c8dbf9442023-09-02T20:08:08ZengMDPI AGCells2073-44092019-08-018881410.3390/cells8080814cells8080814Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in MitosisMeghna Kataria0Hiroyuki Yamano1UCL Cancer Institute, University College London, London WC1E 6DD, UKUCL Cancer Institute, University College London, London WC1E 6DD, UKAccurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic phase and exit from it. A large E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) becomes active during latter stages of mitosis through G1 and marks hundreds of proteins for destruction. Recent studies have revealed the complex interregulation between these two classes of enzymes. In this review, we highlight the direct and indirect mechanisms by which phosphatases and the APC/C mutually influence each other to ensure accurate spatiotemporal and orderly progression through mitosis, with a particular focus on recent insights and conceptual advances.https://www.mdpi.com/2073-4409/8/8/814phosphatasekinaseanaphase-promoting complex/cyclosome (APC/C)cyclin-dependent kinase 1 (Cdk1)cyclinmitosiscell cyclephosphorylationubiquitylation |
| spellingShingle | Meghna Kataria Hiroyuki Yamano Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis Cells phosphatase kinase anaphase-promoting complex/cyclosome (APC/C) cyclin-dependent kinase 1 (Cdk1) cyclin mitosis cell cycle phosphorylation ubiquitylation |
| title | Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis |
| title_full | Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis |
| title_fullStr | Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis |
| title_full_unstemmed | Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis |
| title_short | Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis |
| title_sort | interplay between phosphatases and the anaphase promoting complex cyclosome in mitosis |
| topic | phosphatase kinase anaphase-promoting complex/cyclosome (APC/C) cyclin-dependent kinase 1 (Cdk1) cyclin mitosis cell cycle phosphorylation ubiquitylation |
| url | https://www.mdpi.com/2073-4409/8/8/814 |
| work_keys_str_mv | AT meghnakataria interplaybetweenphosphatasesandtheanaphasepromotingcomplexcyclosomeinmitosis AT hiroyukiyamano interplaybetweenphosphatasesandtheanaphasepromotingcomplexcyclosomeinmitosis |