Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry
Thermogravimetry does not give specific information on residual organic solvents in polymeric matrices unless it is hyphenated with the so-called evolved gas analysis. The purpose of this study was to apply, for the first time, derivative thermogravimetry (DTG) to characterize a residual solvent and...
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MDPI AG
2020-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/7/626 |
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| author | Hyunjin Shim Hongkee Sah |
| author_facet | Hyunjin Shim Hongkee Sah |
| author_sort | Hyunjin Shim |
| collection | DOAJ |
| description | Thermogravimetry does not give specific information on residual organic solvents in polymeric matrices unless it is hyphenated with the so-called evolved gas analysis. The purpose of this study was to apply, for the first time, derivative thermogravimetry (DTG) to characterize a residual solvent and a drug in poly-<i>d,l</i>-lactide-<i>co</i>-glycolide (PLGA) microspheres. Ethyl formate, an ICH class 3 solvent, was used to encapsulate progesterone into microspheres. DTG provided a distinct peak, displaying the onset and end temperatures at which ethyl formate started to evolve from to where it completely escaped out of the microspheres. DTG also gave the area and height of the solvent peak, as well as the temperature of the highest mass change rate of the microspheres. These derivative parameters allowed for the measurement of the amount of residual ethyl formate in the microspheres. Interestingly, progesterone affected not only the residual solvent amount but also these derivative parameters. Another intriguing finding was that there was a linear relationship between progesterone content and the peak height of ethyl formate. The residual solvent data calculated by DTG were quite comparable to those measured by gas chromatography. In summary, DTG could be an efficient and practical quality control tool to evaluate residual solvents and drugs in various polymeric matrices. |
| first_indexed | 2024-03-10T18:41:30Z |
| format | Article |
| id | doaj.art-65f9abe15cc942878eb9b761a4bfb616 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T18:41:30Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
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| series | Pharmaceutics |
| spelling | doaj.art-65f9abe15cc942878eb9b761a4bfb6162023-11-20T05:50:51ZengMDPI AGPharmaceutics1999-49232020-07-0112762610.3390/pharmaceutics12070626Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative ThermogravimetryHyunjin Shim0Hongkee Sah1College of Pharmacy, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 03760, KoreaCollege of Pharmacy, Ewha Womans University, 52 Ewhayeodaegil, Seodaemun-gu, Seoul 03760, KoreaThermogravimetry does not give specific information on residual organic solvents in polymeric matrices unless it is hyphenated with the so-called evolved gas analysis. The purpose of this study was to apply, for the first time, derivative thermogravimetry (DTG) to characterize a residual solvent and a drug in poly-<i>d,l</i>-lactide-<i>co</i>-glycolide (PLGA) microspheres. Ethyl formate, an ICH class 3 solvent, was used to encapsulate progesterone into microspheres. DTG provided a distinct peak, displaying the onset and end temperatures at which ethyl formate started to evolve from to where it completely escaped out of the microspheres. DTG also gave the area and height of the solvent peak, as well as the temperature of the highest mass change rate of the microspheres. These derivative parameters allowed for the measurement of the amount of residual ethyl formate in the microspheres. Interestingly, progesterone affected not only the residual solvent amount but also these derivative parameters. Another intriguing finding was that there was a linear relationship between progesterone content and the peak height of ethyl formate. The residual solvent data calculated by DTG were quite comparable to those measured by gas chromatography. In summary, DTG could be an efficient and practical quality control tool to evaluate residual solvents and drugs in various polymeric matrices.https://www.mdpi.com/1999-4923/12/7/626poly-<i>d,l</i>-lactide-<i>co</i>-glycolidemicrospheresderivative thermogravimetryresidual solventethyl formate |
| spellingShingle | Hyunjin Shim Hongkee Sah Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry Pharmaceutics poly-<i>d,l</i>-lactide-<i>co</i>-glycolide microspheres derivative thermogravimetry residual solvent ethyl formate |
| title | Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry |
| title_full | Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry |
| title_fullStr | Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry |
| title_full_unstemmed | Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry |
| title_short | Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry |
| title_sort | assessment of residual solvent and drug in plga microspheres by derivative thermogravimetry |
| topic | poly-<i>d,l</i>-lactide-<i>co</i>-glycolide microspheres derivative thermogravimetry residual solvent ethyl formate |
| url | https://www.mdpi.com/1999-4923/12/7/626 |
| work_keys_str_mv | AT hyunjinshim assessmentofresidualsolventanddruginplgamicrospheresbyderivativethermogravimetry AT hongkeesah assessmentofresidualsolventanddruginplgamicrospheresbyderivativethermogravimetry |