Hypercortisolism in patients with cholestasis is associated with disease severity

Hypercortisolism in patients with cholestasis is associated with disease severity

Abstract Background Cholestasis might lead to an impairment of adrenal function as suggested by in vitro and in vivo data as well as by clinical findings. Bile acid and adrenal steroid metabolism not only share the receptors farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (...

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Bibliographic Details
Main Authors: Verena Theiler-Schwetz, Hansjörg Schlager, Barbara Obermayer-Pietsch, Tatjana Stojakovic, Günter Fauler, Peter Fickert, Gernot Zollner
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Gastroenterology
Subjects:
Hypothalamic–pituitary–adrenal axis (HPA axis)
Adrenal gland
Bile acids
Cholestasis
Bilirubin
Cortisol
Online Access:https://doi.org/10.1186/s12876-021-02045-4

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