The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study
<p>Abstract</p> <p>Background</p> <p>Reactive arthritis (ReA) is a recognized sequela of infectious gastroenteritis (IGE). However, the population-based incidence of IGE-related ReA is poorly defined, and the risk of disease has not previously been characterized in a mi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-09-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/10/266 |
| _version_ | 1811317129380626432 |
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| author | Curry Jennifer A Riddle Mark S Gormley Robert P Tribble David R Porter Chad K |
| author_facet | Curry Jennifer A Riddle Mark S Gormley Robert P Tribble David R Porter Chad K |
| author_sort | Curry Jennifer A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Reactive arthritis (ReA) is a recognized sequela of infectious gastroenteritis (IGE). However, the population-based incidence of IGE-related ReA is poorly defined, and the risk of disease has not previously been characterized in a military population. The intent of this study was to provide estimates of the incidence and morbidity associated with IGE-related ReA in the U.S. military population.</p> <p>Methods</p> <p>Using active duty US military medical encounter data from the Defense Medical Surveillance System, we conducted a matched case-control study to assess the risk of ReA following IGE. Both specific and nonspecific case definitions were utilized to address ICD-9 coding limitations; these included specific ReA (Reiter's Disease or postdysenteric arthritis) and nonspecific arthritis/arthralgia (N.A.A) (which included several related arthropathy and arthralgia diagnoses). Incidence was estimated using events and the total number of active duty personnel for each year.</p> <p>Results</p> <p>506 cases of specific ReA were identified in active duty personnel between 1999 and 2007. Another 16,365 cases of N.A.A. were identified. Overall incidence was 4.1 (95% CI: 3.7, 4.5) and 132.0 (95% CI, 130.0-134.0) per 100,000 for specific ReA and N.A.A, respectively. Compared to the youngest age category, the incidence of both outcomes increased 7-fold with a concurrent increase in symptom duration for cases over the age of 40. Specific IGE exposures were documented in 1.4% of subjects. After adjusting for potential confounders, there was a significant association between IGE and ReA (specific reactive arthritis OR: 4.42, 95% CI: 2.24, 8.73; N.A.A OR: 1.76, 95% CI: 1.49, 2.07).</p> <p>Conclusions</p> <p>Reactive arthritis may be more common in military populations than previously described. The burden of ReA and strong association with antecedent IGE warrants continued IGE prevention efforts.</p> |
| first_indexed | 2024-04-13T12:01:42Z |
| format | Article |
| id | doaj.art-65fb7d543a2f4ff788db6936a3b38e19 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T12:01:42Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-65fb7d543a2f4ff788db6936a3b38e192022-12-22T02:47:45ZengBMCBMC Infectious Diseases1471-23342010-09-0110126610.1186/1471-2334-10-266The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control studyCurry Jennifer ARiddle Mark SGormley Robert PTribble David RPorter Chad K<p>Abstract</p> <p>Background</p> <p>Reactive arthritis (ReA) is a recognized sequela of infectious gastroenteritis (IGE). However, the population-based incidence of IGE-related ReA is poorly defined, and the risk of disease has not previously been characterized in a military population. The intent of this study was to provide estimates of the incidence and morbidity associated with IGE-related ReA in the U.S. military population.</p> <p>Methods</p> <p>Using active duty US military medical encounter data from the Defense Medical Surveillance System, we conducted a matched case-control study to assess the risk of ReA following IGE. Both specific and nonspecific case definitions were utilized to address ICD-9 coding limitations; these included specific ReA (Reiter's Disease or postdysenteric arthritis) and nonspecific arthritis/arthralgia (N.A.A) (which included several related arthropathy and arthralgia diagnoses). Incidence was estimated using events and the total number of active duty personnel for each year.</p> <p>Results</p> <p>506 cases of specific ReA were identified in active duty personnel between 1999 and 2007. Another 16,365 cases of N.A.A. were identified. Overall incidence was 4.1 (95% CI: 3.7, 4.5) and 132.0 (95% CI, 130.0-134.0) per 100,000 for specific ReA and N.A.A, respectively. Compared to the youngest age category, the incidence of both outcomes increased 7-fold with a concurrent increase in symptom duration for cases over the age of 40. Specific IGE exposures were documented in 1.4% of subjects. After adjusting for potential confounders, there was a significant association between IGE and ReA (specific reactive arthritis OR: 4.42, 95% CI: 2.24, 8.73; N.A.A OR: 1.76, 95% CI: 1.49, 2.07).</p> <p>Conclusions</p> <p>Reactive arthritis may be more common in military populations than previously described. The burden of ReA and strong association with antecedent IGE warrants continued IGE prevention efforts.</p>http://www.biomedcentral.com/1471-2334/10/266 |
| spellingShingle | Curry Jennifer A Riddle Mark S Gormley Robert P Tribble David R Porter Chad K The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study BMC Infectious Diseases |
| title | The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study |
| title_full | The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study |
| title_fullStr | The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study |
| title_full_unstemmed | The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study |
| title_short | The epidemiology of infectious gastroenteritis related reactive arthritis in U.S. military personnel: a case-control study |
| title_sort | epidemiology of infectious gastroenteritis related reactive arthritis in u s military personnel a case control study |
| url | http://www.biomedcentral.com/1471-2334/10/266 |
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