Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines
An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhib...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622000200 |
| Summary: | An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhibit moderate activity against both the representative Gram positive and Gram negative bacteria, suggesting possible scope of using them as antimicrobials. Additionally Suzuki cross-coupling of 5-bromo-2-iminothiazolines with organoboronic acids produced fully substituted 5-aryl-2-iminothiazolines in good yield. |
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| ISSN: | 2211-7156 |