Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines
An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhib...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622000200 |
| _version_ | 1811178128298475520 |
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| author | Chandan Bodhak Subhro Mandal Pia Dey Samir Kumar Mukherjee Animesh Pramanik |
| author_facet | Chandan Bodhak Subhro Mandal Pia Dey Samir Kumar Mukherjee Animesh Pramanik |
| author_sort | Chandan Bodhak |
| collection | DOAJ |
| description | An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhibit moderate activity against both the representative Gram positive and Gram negative bacteria, suggesting possible scope of using them as antimicrobials. Additionally Suzuki cross-coupling of 5-bromo-2-iminothiazolines with organoboronic acids produced fully substituted 5-aryl-2-iminothiazolines in good yield. |
| first_indexed | 2024-04-11T06:14:05Z |
| format | Article |
| id | doaj.art-65fc3b1af2ca451a8fd14b50f313820b |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-11T06:14:05Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-65fc3b1af2ca451a8fd14b50f313820b2022-12-22T04:41:08ZengElsevierResults in Chemistry2211-71562022-01-014100301Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolinesChandan Bodhak0Subhro Mandal1Pia Dey2Samir Kumar Mukherjee3Animesh Pramanik4Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700 009, IndiaDepartment of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700 009, IndiaDepartment of Microbiology, University of Kalyani, Kalyani 741235, IndiaDepartment of Microbiology, University of Kalyani, Kalyani 741235, IndiaDepartment of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700 009, India; Corresponding author.An ultrasound assisted methodology has been developed for rapid synthesis of a series of biologically important 2-iminothiazolines from easily available α-bromoketones and thioureas under solvent- and catalyst-free conditions at room temperature in open air. The 2-iminothiazolines are found to exhibit moderate activity against both the representative Gram positive and Gram negative bacteria, suggesting possible scope of using them as antimicrobials. Additionally Suzuki cross-coupling of 5-bromo-2-iminothiazolines with organoboronic acids produced fully substituted 5-aryl-2-iminothiazolines in good yield.http://www.sciencedirect.com/science/article/pii/S22117156220002002-IminothiazolineUltrasonicationSolvent-freeAntimicrobialsSuzuki cross-coupling |
| spellingShingle | Chandan Bodhak Subhro Mandal Pia Dey Samir Kumar Mukherjee Animesh Pramanik Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines Results in Chemistry 2-Iminothiazoline Ultrasonication Solvent-free Antimicrobials Suzuki cross-coupling |
| title | Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines |
| title_full | Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines |
| title_fullStr | Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines |
| title_full_unstemmed | Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines |
| title_short | Efficient synthesis of functionalized 2-iminothiazolines by ultrasonication under solvent-free conditions and access to 5-aryl-2-iminothiazolines |
| title_sort | efficient synthesis of functionalized 2 iminothiazolines by ultrasonication under solvent free conditions and access to 5 aryl 2 iminothiazolines |
| topic | 2-Iminothiazoline Ultrasonication Solvent-free Antimicrobials Suzuki cross-coupling |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622000200 |
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