Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction
AIM: To evaluate the clinical effectiveness of different methods for moderate to severe meibomian gland dysfunction(MGD)related dry eye.METHODS: The clinical data of 72 patients(144 eyes)with MGD related dry eye treated from March 2020 to September 2021 in the ophthalmology clinic of Xi'an Inte...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-11-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2022/11/202211022.pdf |
| _version_ | 1811191937205534720 |
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| author | Miao Zhang Zhen-Jiao Luo Yu-Feng Ren Wei Ni Lei Yang |
| author_facet | Miao Zhang Zhen-Jiao Luo Yu-Feng Ren Wei Ni Lei Yang |
| author_sort | Miao Zhang |
| collection | DOAJ |
| description | AIM: To evaluate the clinical effectiveness of different methods for moderate to severe meibomian gland dysfunction(MGD)related dry eye.METHODS: The clinical data of 72 patients(144 eyes)with MGD related dry eye treated from March 2020 to September 2021 in the ophthalmology clinic of Xi'an International Medical Center Hospital were retrospectively analyzed. They were divided into moderate group(1/3<meibomian gland absence < 2/3, 37 patients with 74 eyes), and severe group(meibomian gland absence ≥2/3, 35 patients with 70 eyes)according to the absence area of meibomian gland. The patients were randomly divided into group A(fumigation massage of meibomian gland)and group B(fumigation massage of meibomian gland combined with intense pulsed light)according to different therapies. The ocular surface disease index(OSDI)scores, non-invasive tear meniscus height(NITMH), non-invasive average tear film breakup time(NIBUTav)and R-scan analysis were recorded before treatment and 1mo after treatment.RESULTS: Compared with pre-treatment, the OSDI scores of patients in group A and group B were significantly decreased at 1mo after treatment, and the results of NIBUTav and R-scan analysis were significantly improved(P<0.001), while the NITMH had no significant change(P>0.05). In the moderate group, the OSDI scores of group A and group B were significantly decreased, and the results of NIBUTav and R-scan analysis were significantly improved(P<0.01), while NITMH had no significant change(P>0.05). In the severe group, NIBUTav of the patients in group A improved significantly(P<0.001), while there was no significant change in other observation parameters(P>0.05), while the OSDI scores of the patients in group B were significantly decreased. And the results of NIBUTav and R-scan analysis were significantly improved(P<0.001), but there was no significant change in NITMH(P>0.05).CONCLUSION: Both therapies were effective for moderate meibomian gland dysfunction related dry eye, while severe meibomian gland dysfunction related dry eye should be treated with fumigation massage of meibomian gland combined with intense pulsed light. |
| first_indexed | 2024-04-11T23:45:19Z |
| format | Article |
| id | doaj.art-65fcb249063e4e41ac978c5c202a11f3 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-11T23:45:19Z |
| publishDate | 2022-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-65fcb249063e4e41ac978c5c202a11f32022-12-22T03:56:40ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232022-11-0122111877188010.3980/j.issn.1672-5123.2022.11.22202211022Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunctionMiao Zhang0Zhen-Jiao Luo1Yu-Feng Ren2Wei Ni3Lei Yang4Department of Ophthalmology, Xi'an International Medical Center Hospital, Xi'an 710119, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an International Medical Center Hospital, Xi'an 710119, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an International Medical Center Hospital, Xi'an 710119, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an International Medical Center Hospital, Xi'an 710119, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an International Medical Center Hospital, Xi'an 710119, Shaanxi Province, ChinaAIM: To evaluate the clinical effectiveness of different methods for moderate to severe meibomian gland dysfunction(MGD)related dry eye.METHODS: The clinical data of 72 patients(144 eyes)with MGD related dry eye treated from March 2020 to September 2021 in the ophthalmology clinic of Xi'an International Medical Center Hospital were retrospectively analyzed. They were divided into moderate group(1/3<meibomian gland absence < 2/3, 37 patients with 74 eyes), and severe group(meibomian gland absence ≥2/3, 35 patients with 70 eyes)according to the absence area of meibomian gland. The patients were randomly divided into group A(fumigation massage of meibomian gland)and group B(fumigation massage of meibomian gland combined with intense pulsed light)according to different therapies. The ocular surface disease index(OSDI)scores, non-invasive tear meniscus height(NITMH), non-invasive average tear film breakup time(NIBUTav)and R-scan analysis were recorded before treatment and 1mo after treatment.RESULTS: Compared with pre-treatment, the OSDI scores of patients in group A and group B were significantly decreased at 1mo after treatment, and the results of NIBUTav and R-scan analysis were significantly improved(P<0.001), while the NITMH had no significant change(P>0.05). In the moderate group, the OSDI scores of group A and group B were significantly decreased, and the results of NIBUTav and R-scan analysis were significantly improved(P<0.01), while NITMH had no significant change(P>0.05). In the severe group, NIBUTav of the patients in group A improved significantly(P<0.001), while there was no significant change in other observation parameters(P>0.05), while the OSDI scores of the patients in group B were significantly decreased. And the results of NIBUTav and R-scan analysis were significantly improved(P<0.001), but there was no significant change in NITMH(P>0.05).CONCLUSION: Both therapies were effective for moderate meibomian gland dysfunction related dry eye, while severe meibomian gland dysfunction related dry eye should be treated with fumigation massage of meibomian gland combined with intense pulsed light.http://ies.ijo.cn/cn_publish/2022/11/202211022.pdfmeibomian gland dysfunctionintense pulse lightmeibomian gland massagedry eyeeffectiveness |
| spellingShingle | Miao Zhang Zhen-Jiao Luo Yu-Feng Ren Wei Ni Lei Yang Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction Guoji Yanke Zazhi meibomian gland dysfunction intense pulse light meibomian gland massage dry eye effectiveness |
| title | Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| title_full | Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| title_fullStr | Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| title_full_unstemmed | Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| title_short | Effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| title_sort | effectiveness of different methods in the treatment of moderate to severe meibomian gland dysfunction |
| topic | meibomian gland dysfunction intense pulse light meibomian gland massage dry eye effectiveness |
| url | http://ies.ijo.cn/cn_publish/2022/11/202211022.pdf |
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