A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants.

A polymeric protein induces specific cytotoxicity in a TLR4 dependent manner in the absence of adjuvants.

Lumazine synthase from Brucella spp. (BLS) is a highly immunogenic decameric protein. It is possible to insert foreign peptides or proteins at its ten-amino acid termini. These chimeras elicit systemic and oral immunity without adjuvants, which are commonly needed in the formulation of subunit-based...

Full description

Bibliographic Details
Main Authors: Paula M Berguer, Vanina A Alzogaray, Andrés Hugo Rossi, Juliana Mundiñano, Isabel Piazzon, Fernando A Goldbaum
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454435?pdf=render

Similar Items

Similar Items