Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis
A 66-year-old man with a previous history of advanced prostate cancer failing complete androgen blockade, docetaxel chemotherapy, denosumab, and abiraterone acetate as judged by persistent high serum levels of prostate specific antigen presented with exertional dyspnea, normocytic anemia, and thromb...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Clinics and Practice |
| Subjects: | |
| Online Access: | https://clinicsandpractice.org/index.php/cp/article/view/1124 |
| _version_ | 1828746410565042176 |
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| author | Frank Sheng Fan Chung-Fan Yang |
| author_facet | Frank Sheng Fan Chung-Fan Yang |
| author_sort | Frank Sheng Fan |
| collection | DOAJ |
| description | A 66-year-old man with a previous history of advanced prostate cancer failing complete androgen blockade, docetaxel chemotherapy, denosumab, and abiraterone acetate as judged by persistent high serum levels of prostate specific antigen presented with exertional dyspnea, normocytic anemia, and thrombocytopenia. Leukoerythroblastosis was noted in his peripheral blood. Bone marrow examination disclosed diffuse bone marrow carcinomatosis from prostate cancer. Prolonged activated partial thromboplastin time, prothrombin time, and an extremely elevated serum level of D-dimer led to a diagnosis of disseminated intravascular coagulation. Magnetic resonance imaging of spine revealed extensive bone marrow involvement but bone scan showed only scanty bony metastasis. We like to call attention to the importance of prompt bone marrow examination once recognizing leukoerythroblastosis in patients with advanced prostate cancer. Survey of a possible coexistent disseminated intravascular coagulation is as well strongly recommended in this condition. |
| first_indexed | 2024-04-14T04:23:59Z |
| format | Article |
| id | doaj.art-65ff972b76394831a87e7f3f290ad448 |
| institution | Directory Open Access Journal |
| issn | 2039-7275 2039-7283 |
| language | English |
| last_indexed | 2024-04-14T04:23:59Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj.art-65ff972b76394831a87e7f3f290ad4482022-12-22T02:12:22ZengMDPI AGClinics and Practice2039-72752039-72832019-05-019210.4081/cp.2019.1124Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosisFrank Sheng Fan0Chung-Fan Yang1Section of Hematology and Oncology, Department of Medicine, Ministry of Health and Welfare Changhua Hospital, Chang-Hua CountyDepartment of Pathology, Ministry of Health and Welfare Changhua Hospital, Chang-Hua CountyA 66-year-old man with a previous history of advanced prostate cancer failing complete androgen blockade, docetaxel chemotherapy, denosumab, and abiraterone acetate as judged by persistent high serum levels of prostate specific antigen presented with exertional dyspnea, normocytic anemia, and thrombocytopenia. Leukoerythroblastosis was noted in his peripheral blood. Bone marrow examination disclosed diffuse bone marrow carcinomatosis from prostate cancer. Prolonged activated partial thromboplastin time, prothrombin time, and an extremely elevated serum level of D-dimer led to a diagnosis of disseminated intravascular coagulation. Magnetic resonance imaging of spine revealed extensive bone marrow involvement but bone scan showed only scanty bony metastasis. We like to call attention to the importance of prompt bone marrow examination once recognizing leukoerythroblastosis in patients with advanced prostate cancer. Survey of a possible coexistent disseminated intravascular coagulation is as well strongly recommended in this condition.https://clinicsandpractice.org/index.php/cp/article/view/1124LeukoerythroblastosisBone marrow carcinomatosisCastration-resistant prostate cancer |
| spellingShingle | Frank Sheng Fan Chung-Fan Yang Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis Clinics and Practice Leukoerythroblastosis Bone marrow carcinomatosis Castration-resistant prostate cancer |
| title | Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis |
| title_full | Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis |
| title_fullStr | Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis |
| title_full_unstemmed | Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis |
| title_short | Leukoerythroblastosis in castration-resistant prostate cancer: A clue to diffuse bone marrow carcinomatosis |
| title_sort | leukoerythroblastosis in castration resistant prostate cancer a clue to diffuse bone marrow carcinomatosis |
| topic | Leukoerythroblastosis Bone marrow carcinomatosis Castration-resistant prostate cancer |
| url | https://clinicsandpractice.org/index.php/cp/article/view/1124 |
| work_keys_str_mv | AT frankshengfan leukoerythroblastosisincastrationresistantprostatecanceracluetodiffusebonemarrowcarcinomatosis AT chungfanyang leukoerythroblastosisincastrationresistantprostatecanceracluetodiffusebonemarrowcarcinomatosis |