Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping
The current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances are rapidly being developed, the need for complimentary methods for monitoring is crucial to ensure the integrity of the racing industry is upheld. Lipidomics is a gro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/1/312 |
| _version_ | 1797440333972242432 |
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| author | Kathy Tou Adam Cawley Christopher Bowen David P. Bishop Shanlin Fu |
| author_facet | Kathy Tou Adam Cawley Christopher Bowen David P. Bishop Shanlin Fu |
| author_sort | Kathy Tou |
| collection | DOAJ |
| description | The current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances are rapidly being developed, the need for complimentary methods for monitoring is crucial to ensure the integrity of the racing industry is upheld. Lipidomics is a growing field involved in the characterisation of lipids, their function and metabolism in a biological system. Different lipids have various biological effects throughout the equine system including platelet aggregation and inflammation. A certain class of lipids that are being reviewed are the eicosanoids (inflammatory markers). The use of eicosanoids as a complementary method for monitoring has become increasingly popular with various studies completed to highlight their potential. Studies including various corticosteroids, non-steroidal anti-inflammatories and cannabidiol have been reviewed to highlight the progress lipidomics has had in contributing to the equine anti-doping industry. This review has explored the techniques used to prepare and analyse samples for lipidomic investigations in addition to the statistical analysis and potential for lipidomics to be used for a longitudinal assessment in the equine anti-doping industry. |
| first_indexed | 2024-03-09T12:05:41Z |
| format | Article |
| id | doaj.art-660294f0ebaf43db969fa006a6ce2d38 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T12:05:41Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-660294f0ebaf43db969fa006a6ce2d382023-11-30T22:57:53ZengMDPI AGMolecules1420-30492022-12-0128131210.3390/molecules28010312Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-DopingKathy Tou0Adam Cawley1Christopher Bowen2David P. Bishop3Shanlin Fu4Centre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, AustraliaAustralian Racing Forensic Laboratory, Racing NSW, Sydney, NSW 2000, AustraliaMass Spectrometry Business Unit, Shimadzu Scientific Instruments (Australasia), Sydney, NSW 2116, AustraliaHyphenated Mass Spectrometry Laboratory (HyMAS), University of Technology, Sydney, NSW 2007, AustraliaCentre for Forensic Science, University of Technology Sydney, Sydney, NSW 2007, AustraliaThe current approach to equine anti-doping is focused on the targeted detection of prohibited substances. However, as new substances are rapidly being developed, the need for complimentary methods for monitoring is crucial to ensure the integrity of the racing industry is upheld. Lipidomics is a growing field involved in the characterisation of lipids, their function and metabolism in a biological system. Different lipids have various biological effects throughout the equine system including platelet aggregation and inflammation. A certain class of lipids that are being reviewed are the eicosanoids (inflammatory markers). The use of eicosanoids as a complementary method for monitoring has become increasingly popular with various studies completed to highlight their potential. Studies including various corticosteroids, non-steroidal anti-inflammatories and cannabidiol have been reviewed to highlight the progress lipidomics has had in contributing to the equine anti-doping industry. This review has explored the techniques used to prepare and analyse samples for lipidomic investigations in addition to the statistical analysis and potential for lipidomics to be used for a longitudinal assessment in the equine anti-doping industry.https://www.mdpi.com/1420-3049/28/1/312lipidomicsreviewanalyticalcorticosteroidsNSAIDs |
| spellingShingle | Kathy Tou Adam Cawley Christopher Bowen David P. Bishop Shanlin Fu Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping Molecules lipidomics review analytical corticosteroids NSAIDs |
| title | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping |
| title_full | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping |
| title_fullStr | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping |
| title_full_unstemmed | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping |
| title_short | Towards Non-Targeted Screening of Lipid Biomarkers for Improved Equine Anti-Doping |
| title_sort | towards non targeted screening of lipid biomarkers for improved equine anti doping |
| topic | lipidomics review analytical corticosteroids NSAIDs |
| url | https://www.mdpi.com/1420-3049/28/1/312 |
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