Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma
Abstract Objective LncARSR (lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980) is a newly identified lncRNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression. This study aimed to explore the association of lncARS...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2160 |
| _version_ | 1818275715962896384 |
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| author | Qianwei Xing Ran Li Aiming Xu Zhiqiang Qin Jinyuan Tang Lei Zhang Min Tang Peng Han Wei Wang Chao Qin Mulong Du Wei Zhang |
| author_facet | Qianwei Xing Ran Li Aiming Xu Zhiqiang Qin Jinyuan Tang Lei Zhang Min Tang Peng Han Wei Wang Chao Qin Mulong Du Wei Zhang |
| author_sort | Qianwei Xing |
| collection | DOAJ |
| description | Abstract Objective LncARSR (lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980) is a newly identified lncRNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression. This study aimed to explore the association of lncARSR tagSNPs with the risk and prognosis of RCC. Methods In this study, a 2‐stage case‐control study was performed to evaluate the association between 2 tagging SNPs (rs1417080 and rs7859384) and RCC susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by unconditional logistic regression analyses. Different survival time was estimated by the Kaplan‐Meier method and compared by the Log‐rank test. Hazard ratios (HRs) and their 95% CIs were calculated to determine predictive factors by Cox proportion hazards model. Results When combing discovery and validation sets together, rs7859384 was determined to be significantly associated with the decreased RCC risk with all P < 0.05 in 4 models (co‐dominant model, additive model, dominant model and recessive model). stratified analyses showed prominent risk effect of SNP rs7859384 GA/GG genotypes was found in clinical subgroups of stage I and stage II (P = 0.009, OR = 0.77, 95% CI = 0.64‐0.94) and individuals with clear cell RCC (P = 0.014, OR = 0.79, 95% CI = 0.65‐0.95). A protective effect of SNP rs7859384 GA/GG genotypes was observed among individuals with BMI > 24 (P = 0.025, OR = 0.74, 95% CI = 0.56‐0.96), without hypertension (P = 0.037, OR = 0.79, 95% CI = 0.63‐0.99), without family history of cancer (P = 0.048, OR = 0.83, 95% CI = 0.68‐1.00). Survival analyses revealed individuals with GA/GG genotypes had higher survival rate compared with the corresponding AA wild genotypes in the dominant model (log‐rank P = 0.005, adjusted HR = 0.34, 95% CI = 0.16‐0.73). Conclusion This study suggests that rs7859384 of lncARSR was associated with RCC susceptibility and may act as a prognostic biomarker for patients with RCC. |
| first_indexed | 2024-12-12T22:34:10Z |
| format | Article |
| id | doaj.art-6605cee32a334969849fc498f3839d26 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-12T22:34:10Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-6605cee32a334969849fc498f3839d262022-12-22T00:09:32ZengWileyCancer Medicine2045-76342019-06-01862886289610.1002/cam4.2160Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinomaQianwei Xing0Ran Li1Aiming Xu2Zhiqiang Qin3Jinyuan Tang4Lei Zhang5Min Tang6Peng Han7Wei Wang8Chao Qin9Mulong Du10Wei Zhang11Department of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology Surgery Nanjing First Hospital, Nanjing Medical University Nanjing ChinaDepartment of Urology Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaDepartment of Biostatistics, School of Public Health Nanjing Medical University Nanjing ChinaDepartment of Urology The First Affiliated Hospital of Nanjing Medical University Nanjing ChinaAbstract Objective LncARSR (lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980) is a newly identified lncRNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression. This study aimed to explore the association of lncARSR tagSNPs with the risk and prognosis of RCC. Methods In this study, a 2‐stage case‐control study was performed to evaluate the association between 2 tagging SNPs (rs1417080 and rs7859384) and RCC susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by unconditional logistic regression analyses. Different survival time was estimated by the Kaplan‐Meier method and compared by the Log‐rank test. Hazard ratios (HRs) and their 95% CIs were calculated to determine predictive factors by Cox proportion hazards model. Results When combing discovery and validation sets together, rs7859384 was determined to be significantly associated with the decreased RCC risk with all P < 0.05 in 4 models (co‐dominant model, additive model, dominant model and recessive model). stratified analyses showed prominent risk effect of SNP rs7859384 GA/GG genotypes was found in clinical subgroups of stage I and stage II (P = 0.009, OR = 0.77, 95% CI = 0.64‐0.94) and individuals with clear cell RCC (P = 0.014, OR = 0.79, 95% CI = 0.65‐0.95). A protective effect of SNP rs7859384 GA/GG genotypes was observed among individuals with BMI > 24 (P = 0.025, OR = 0.74, 95% CI = 0.56‐0.96), without hypertension (P = 0.037, OR = 0.79, 95% CI = 0.63‐0.99), without family history of cancer (P = 0.048, OR = 0.83, 95% CI = 0.68‐1.00). Survival analyses revealed individuals with GA/GG genotypes had higher survival rate compared with the corresponding AA wild genotypes in the dominant model (log‐rank P = 0.005, adjusted HR = 0.34, 95% CI = 0.16‐0.73). Conclusion This study suggests that rs7859384 of lncARSR was associated with RCC susceptibility and may act as a prognostic biomarker for patients with RCC.https://doi.org/10.1002/cam4.2160LncARSRrenal cell carcinomaSNPs |
| spellingShingle | Qianwei Xing Ran Li Aiming Xu Zhiqiang Qin Jinyuan Tang Lei Zhang Min Tang Peng Han Wei Wang Chao Qin Mulong Du Wei Zhang Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma Cancer Medicine LncARSR renal cell carcinoma SNPs |
| title | Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma |
| title_full | Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma |
| title_fullStr | Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma |
| title_full_unstemmed | Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma |
| title_short | Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma |
| title_sort | genetic variants in a long noncoding rna related to sunitinib resistance predict risk and survival of patients with renal cell carcinoma |
| topic | LncARSR renal cell carcinoma SNPs |
| url | https://doi.org/10.1002/cam4.2160 |
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