Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia
<p>Abstract</p> <p>Objective</p> <p>To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia (SAA).</p> <p>Methods</p> <p>A total of 25 patients with SAA received enh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Journal of Hematology & Oncology |
| Online Access: | http://www.jhoonline.org/content/4/1/27 |
| _version_ | 1818562453180514304 |
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| author | Fang Yuan Yu Zhe Ge Linfu Zhou Fang Kong Fansheng |
| author_facet | Fang Yuan Yu Zhe Ge Linfu Zhou Fang Kong Fansheng |
| author_sort | Fang Yuan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Objective</p> <p>To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia (SAA).</p> <p>Methods</p> <p>A total of 25 patients with SAA received enhanced, intensive, immuno-suppressive therapy and a cord blood transfusion. Therapy protocol: Anti-thymocyte globulin (ATG) 2.5 mg/(kg•d) × 5d; Cyclophosphamide 50 mg/(kg•d) × 2d; cyclosporin A (CsA) maintenance therapy.</p> <p>Result</p> <p>25 patients were enrolled. 18 underwent a complete recovery, 4 made significant improvements, 1 did not respond, and 2 died. Therefore, the efficacy rate was 88%. The median follow-up time was 35 months (range 13-47 months), and the 3-year overall survival rate was 92%. Patients rapidly achieved reconstitution of hematopoiesis. The median time to neutrophil ANC > 0.5 × 10<sup>9</sup>/L was 18 days (range 8-36), platelets >20 × 10<sup>9</sup>/L was 34 days (range 12-123), and Hb > 100 g/L 95 dyas (range 35-173).</p> <p>Conclusion</p> <p>Enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support may be an effective option for SAA therapy.</p> |
| first_indexed | 2024-12-14T01:03:56Z |
| format | Article |
| id | doaj.art-66074ecbdc744a78a9d31171a416efed |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-14T01:03:56Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-66074ecbdc744a78a9d31171a416efed2022-12-21T23:23:04ZengBMCJournal of Hematology & Oncology1756-87222011-06-01412710.1186/1756-8722-4-27Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemiaFang YuanYu ZheGe LinfuZhou FangKong Fansheng<p>Abstract</p> <p>Objective</p> <p>To evaluate the efficacy of enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support for severe aplastic anemia (SAA).</p> <p>Methods</p> <p>A total of 25 patients with SAA received enhanced, intensive, immuno-suppressive therapy and a cord blood transfusion. Therapy protocol: Anti-thymocyte globulin (ATG) 2.5 mg/(kg•d) × 5d; Cyclophosphamide 50 mg/(kg•d) × 2d; cyclosporin A (CsA) maintenance therapy.</p> <p>Result</p> <p>25 patients were enrolled. 18 underwent a complete recovery, 4 made significant improvements, 1 did not respond, and 2 died. Therefore, the efficacy rate was 88%. The median follow-up time was 35 months (range 13-47 months), and the 3-year overall survival rate was 92%. Patients rapidly achieved reconstitution of hematopoiesis. The median time to neutrophil ANC > 0.5 × 10<sup>9</sup>/L was 18 days (range 8-36), platelets >20 × 10<sup>9</sup>/L was 34 days (range 12-123), and Hb > 100 g/L 95 dyas (range 35-173).</p> <p>Conclusion</p> <p>Enhanced, intensive, immuno-suppressive therapy with umbilical cord blood support may be an effective option for SAA therapy.</p>http://www.jhoonline.org/content/4/1/27 |
| spellingShingle | Fang Yuan Yu Zhe Ge Linfu Zhou Fang Kong Fansheng Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia Journal of Hematology & Oncology |
| title | Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| title_full | Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| title_fullStr | Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| title_full_unstemmed | Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| title_short | Clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| title_sort | clinical observations on intensive immunosuppressive therapy combined with umbilical cord blood support for the treatment of severe aplastic anemia |
| url | http://www.jhoonline.org/content/4/1/27 |
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