Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy
Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel a...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-02-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21003236 |
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| author | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng |
| author_facet | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng |
| author_sort | Meng Li |
| collection | DOAJ |
| description | Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements. |
| first_indexed | 2024-04-24T08:33:25Z |
| format | Article |
| id | doaj.art-66086072369b4c638e2c240e5b7cf23e |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:33:25Z |
| publishDate | 2022-02-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-66086072369b4c638e2c240e5b7cf23e2024-04-16T18:44:32ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-02-018309324Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategyMeng Li0Jiaxiang Bai1Huaqiang Tao2Li Hao3Weiling Yin4Xiaoxue Ren5Ang Gao6Ning Li7Miao Wang8Shiyuan Fang9Yaozeng Xu10Liang Chen11Huilin Yang12Huaiyu Wang13Guoqing Pan14Dechun Geng15Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China; Department of Orthopaedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, 17 Lujiang Road, Hefei, 230001, Anhui, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, 17 Lujiang Road, Hefei, 230001, Anhui, ChinaInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, ChinaCenter for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, ChinaCenter for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of USTC, University of Science and Technology of China, 17 Lujiang Road, Hefei, 230001, Anhui, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, ChinaCenter for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, Guangdong, China; Corresponding author.Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China; Corresponding author.Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, China; Corresponding author.Polyetheretherketone (PEEK) has been widely used as orthopedic and dental materials due to excellent mechanical and physicochemical tolerance. However, its biological inertness, poor osteoinduction, and weak antibacterial activity make the clinical applications in a dilemma. Inspired by the mussel adhesion mechanism, here we reported a biomimetic surface strategy for rational integration and optimization of anti-infectivity and osteo-inductivity onto PEEK surfaces using a mussel foot proteins (Mfps)-mimic peptide with clickable azido terminal. The peptide enables mussel-like adhesion on PEEK biomaterial surfaces, leaving azido groups for the further steps of biofunctionalizations. In this study, antimicrobial peptide (AMP) and osteogenic growth peptide (OGP) were bioorthogonally clicked on the azido-modified PEEK biomaterials to obtain a dual-effect of host defense and tissue repair. Since bioorthogonal clicking allows precise collocation between AMP and OGP through changing their feeding molar ratios, an optimal PEEK surface was finally obtained in this research, which could long-term inhibit bacterial growth, stabilize bone homeostasis and facilitate interfacial bone regeneration. In a word, this upgraded mussel surface strategy proposed in this study is promising for the surface bioengineering of inert medical implants, in particular, achieving rational integration of multiple biofunctions to match clinical requirements.http://www.sciencedirect.com/science/article/pii/S2452199X21003236Surface biomodificationPolyetheretherketoneAnti-infectivity and osteo-inductivityMussel adhesionBioorthogonal chemistry |
| spellingShingle | Meng Li Jiaxiang Bai Huaqiang Tao Li Hao Weiling Yin Xiaoxue Ren Ang Gao Ning Li Miao Wang Shiyuan Fang Yaozeng Xu Liang Chen Huilin Yang Huaiyu Wang Guoqing Pan Dechun Geng Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy Bioactive Materials Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry |
| title | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_full | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_fullStr | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_full_unstemmed | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_short | Rational integration of defense and repair synergy on PEEK osteoimplants via biomimetic peptide clicking strategy |
| title_sort | rational integration of defense and repair synergy on peek osteoimplants via biomimetic peptide clicking strategy |
| topic | Surface biomodification Polyetheretherketone Anti-infectivity and osteo-inductivity Mussel adhesion Bioorthogonal chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21003236 |
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