ADP-Hep-Induced Liquid Phase Condensation of TIFA-TRAF6 Activates ALPK1/TIFA-Dependent Innate Immune Responses
The ALPK1 (alpha-kinase 1)-TIFA (TRAF-interacting protein with fork head-associated domain)-TRAF6 signaling pathway plays a pivotal role in regulating inflammatory processes, with TIFA and TRAF6 serving as key molecules in this cascade. Despite its significance, the functional mechanism of TIFA-TRAF...
Main Authors: | Liping Li, Jia Wang, Xincheng Zhong, Yaoyao Jiang, Gaofeng Pei, Xikang Yang, Kaixiang Zhang, Siqi Shen, Xue Jin, Gaoge Sun, Chaofei Su, Shuzhen Chen, Hang Yin |
---|---|
Format: | Article |
Language: | English |
Published: |
American Association for the Advancement of Science
2024-01-01
|
Series: | Research |
Online Access: | https://spj.science.org/doi/10.34133/research.0315 |
Similar Items
-
Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation
by: Camille Martin-Gallausiaux, et al.
Published: (2024-12-01) -
Helicobacter pylori regulates TIFA turnover in gastric epithelial cells.
by: Olga Sokolova, et al.
Published: (2023-06-01) -
Kajian musik Tifa Totobuang sebagai daya tarik wisata di Kota Ambon
by: , LESILOLO, Natalia Christea, et al.
Published: (2008) -
ARTI TIFA DALAM MUSIK TARIAN ADAT DI SENTANI PADA FESTIVAL DANAU SENTANI 2010 DI KABUPATEN JAYAPURA PAPUA
by: , R.R. BUDIASTUTI WULAN UNING SRI KASWARI, et al.
Published: (2012) -
In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants
by: Diego García-Weber, et al.
Published: (2023-04-01)