Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication
Coronavirus disease-19 (COVID-19) is still affecting the lives of people around the globe and remains a major public health threat. Lipid levels in the host cells have been shown to promote SARS-CoV-2 replication, and since the start of COVID-19 pandemic, several studies have linked obesity and othe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/4/1026 |
| _version_ | 1797603136188186624 |
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| author | Tatjana Seitz Christian Setz Pia Rauch Ulrich Schubert Claus Hellerbrand |
| author_facet | Tatjana Seitz Christian Setz Pia Rauch Ulrich Schubert Claus Hellerbrand |
| author_sort | Tatjana Seitz |
| collection | DOAJ |
| description | Coronavirus disease-19 (COVID-19) is still affecting the lives of people around the globe and remains a major public health threat. Lipid levels in the host cells have been shown to promote SARS-CoV-2 replication, and since the start of COVID-19 pandemic, several studies have linked obesity and other components of the metabolic syndrome with severity of illness, as well as mortality in patients with COVID-19. The aim of this study was to obtain insights into the pathophysiological mechanisms of these associations. First, we established an in vitro model simulating high fatty acid levels and showed that this situation induced the uptake of fatty acids and triglyceride accumulation in human Calu-3 lung cells. Importantly, we found that lipid accumulation significantly enhanced the replication of SARS-CoV-2 Wuhan type or the variant of concern, Delta, in Calu-3 cells. In summary, these findings indicate that hyperlipidemia as found in patients with obesity promotes viral replication and herewith the disease course of COVID-19. |
| first_indexed | 2024-03-11T04:26:10Z |
| format | Article |
| id | doaj.art-661063ef8737428d861bf8a7087b7afc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:10Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-661063ef8737428d861bf8a7087b7afc2023-11-17T21:47:08ZengMDPI AGViruses1999-49152023-04-01154102610.3390/v15041026Lipid Accumulation in Host Cells Promotes SARS-CoV-2 ReplicationTatjana Seitz0Christian Setz1Pia Rauch2Ulrich Schubert3Claus Hellerbrand4Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, GermanyInstitute of Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-91054 Erlangen, GermanyInstitute of Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-91054 Erlangen, GermanyInstitute of Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), D-91054 Erlangen, GermanyInstitute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91054 Erlangen, GermanyCoronavirus disease-19 (COVID-19) is still affecting the lives of people around the globe and remains a major public health threat. Lipid levels in the host cells have been shown to promote SARS-CoV-2 replication, and since the start of COVID-19 pandemic, several studies have linked obesity and other components of the metabolic syndrome with severity of illness, as well as mortality in patients with COVID-19. The aim of this study was to obtain insights into the pathophysiological mechanisms of these associations. First, we established an in vitro model simulating high fatty acid levels and showed that this situation induced the uptake of fatty acids and triglyceride accumulation in human Calu-3 lung cells. Importantly, we found that lipid accumulation significantly enhanced the replication of SARS-CoV-2 Wuhan type or the variant of concern, Delta, in Calu-3 cells. In summary, these findings indicate that hyperlipidemia as found in patients with obesity promotes viral replication and herewith the disease course of COVID-19.https://www.mdpi.com/1999-4915/15/4/1026SARS-CoV-2COVID-19fatty acidobesityhyperlipidemiacoronavirus |
| spellingShingle | Tatjana Seitz Christian Setz Pia Rauch Ulrich Schubert Claus Hellerbrand Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication Viruses SARS-CoV-2 COVID-19 fatty acid obesity hyperlipidemia coronavirus |
| title | Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication |
| title_full | Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication |
| title_fullStr | Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication |
| title_full_unstemmed | Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication |
| title_short | Lipid Accumulation in Host Cells Promotes SARS-CoV-2 Replication |
| title_sort | lipid accumulation in host cells promotes sars cov 2 replication |
| topic | SARS-CoV-2 COVID-19 fatty acid obesity hyperlipidemia coronavirus |
| url | https://www.mdpi.com/1999-4915/15/4/1026 |
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