Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis
As a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous subgroups according to their structure and function. MMP contents in the human body are strictly regulated, and their synthesis, activ...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046810/full |
| _version_ | 1797984891165474816 |
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| author | Ruo-Lan Li Hu-Xinyue Duan Qi Liang Yong-Liang Huang Ling-Yu Wang Qing Zhang Chun-Jie Wu Shu-Qin Liu Wei Peng |
| author_facet | Ruo-Lan Li Hu-Xinyue Duan Qi Liang Yong-Liang Huang Ling-Yu Wang Qing Zhang Chun-Jie Wu Shu-Qin Liu Wei Peng |
| author_sort | Ruo-Lan Li |
| collection | DOAJ |
| description | As a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous subgroups according to their structure and function. MMP contents in the human body are strictly regulated, and their synthesis, activation and inhibition processes should be kept in a certain balance; otherwise, this would result in the occurrence of various diseases. Rheumatoid arthritis (RA) is a known immune-mediated systemic inflammatory disease that is affected by a variety of endogenous and exogenous factors. In RA development, MMPs act as important mediators of inflammation and participate in the degradation of extracellular matrix substrates and digestion of fibrillar collagens, leading to the destruction of joint structures. Interestingly, increasing evidence has suggested that herbal medicines have many advantages in RA due to their multitarget properties. In this paper, literature was obtained through electronic databases, including the Web of Science, PubMed, Google Scholar, Springer, and CNKI (Chinese). After classification and analysis, herbal medicines were found to inhibit the inflammatory process of RA by regulating MMPs and protecting joint structures. However, further preclinical and clinical studies are needed to support this view before these herbal medicines can be developed into drugs with actual application to the disease. |
| first_indexed | 2024-04-11T07:10:10Z |
| format | Article |
| id | doaj.art-6611b18e88634def81982bc2f3b76187 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T07:10:10Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6611b18e88634def81982bc2f3b761872022-12-22T04:38:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10468101046810Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritisRuo-Lan Li0Hu-Xinyue Duan1Qi Liang2Yong-Liang Huang3Ling-Yu Wang4Qing Zhang5Chun-Jie Wu6Shu-Qin Liu7Wei Peng8State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaAs a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous subgroups according to their structure and function. MMP contents in the human body are strictly regulated, and their synthesis, activation and inhibition processes should be kept in a certain balance; otherwise, this would result in the occurrence of various diseases. Rheumatoid arthritis (RA) is a known immune-mediated systemic inflammatory disease that is affected by a variety of endogenous and exogenous factors. In RA development, MMPs act as important mediators of inflammation and participate in the degradation of extracellular matrix substrates and digestion of fibrillar collagens, leading to the destruction of joint structures. Interestingly, increasing evidence has suggested that herbal medicines have many advantages in RA due to their multitarget properties. In this paper, literature was obtained through electronic databases, including the Web of Science, PubMed, Google Scholar, Springer, and CNKI (Chinese). After classification and analysis, herbal medicines were found to inhibit the inflammatory process of RA by regulating MMPs and protecting joint structures. However, further preclinical and clinical studies are needed to support this view before these herbal medicines can be developed into drugs with actual application to the disease.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046810/fullmatrix metalloproteinasesrheumatoid arthritisherbal medicinestherapeuticstrategy |
| spellingShingle | Ruo-Lan Li Hu-Xinyue Duan Qi Liang Yong-Liang Huang Ling-Yu Wang Qing Zhang Chun-Jie Wu Shu-Qin Liu Wei Peng Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis Frontiers in Immunology matrix metalloproteinases rheumatoid arthritis herbal medicines therapeutic strategy |
| title | Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis |
| title_full | Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis |
| title_fullStr | Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis |
| title_full_unstemmed | Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis |
| title_short | Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis |
| title_sort | targeting matrix metalloproteases a promising strategy for herbal medicines to treat rheumatoid arthritis |
| topic | matrix metalloproteinases rheumatoid arthritis herbal medicines therapeutic strategy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1046810/full |
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