INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR
Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic is morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin w...
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| Format: | Article |
| Language: | English |
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Gdańsk University of Technology
2014-10-01
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| Series: | TASK Quarterly |
| Subjects: | |
| Online Access: | https://journal.mostwiedzy.pl/TASKQuarterly/article/view/1895 |
| _version_ | 1818264446751997952 |
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| author | AGNIESZKA KARCZYŃSKA BARTŁOMIEJ ZABOROWSKI MAGDALENA ŚLUSARZ |
| author_facet | AGNIESZKA KARCZYŃSKA BARTŁOMIEJ ZABOROWSKI MAGDALENA ŚLUSARZ |
| author_sort | AGNIESZKA KARCZYŃSKA |
| collection | DOAJ |
| description |
Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic is morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin was discovered as another potent analgesic [Montecucchi P C et al. 1981 Int. J. Pept. Protein Res. 17 275]. Unfortunately, this peptide is not resistant to enzymatic metabolism [Kisara K et al. 1986 Br. J. Pharmacol. 87 183; Sasaki Y et al. 1985 Neuropeptides 5 391]. The objective of this study is to search for new opioid analgesics by investigation of interactions between dermorphin analogs and the µ-opioid receptor using molecular modeling methods. MOPR (µ-Opioid Peptide Receptor) complexes with several ligands (with known biological activity) were modeled to explain how the structure of the complex was related to the biological activity. The investigated dermorphin analogs containing [DMT1, D-Arg2] (especially tetrapeptides) may become a good alternative for the currently used analgesics.
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| first_indexed | 2024-12-12T19:35:03Z |
| format | Article |
| id | doaj.art-6611f1bc5e654b7cba0967b440fa1fd4 |
| institution | Directory Open Access Journal |
| issn | 1428-6394 |
| language | English |
| last_indexed | 2024-12-12T19:35:03Z |
| publishDate | 2014-10-01 |
| publisher | Gdańsk University of Technology |
| record_format | Article |
| series | TASK Quarterly |
| spelling | doaj.art-6611f1bc5e654b7cba0967b440fa1fd42022-12-22T00:14:20ZengGdańsk University of TechnologyTASK Quarterly1428-63942014-10-0118410.17466/TQ2014/18.4/PINVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTORAGNIESZKA KARCZYŃSKA0BARTŁOMIEJ ZABOROWSKI1MAGDALENA ŚLUSARZ2University of Gdansk, Department of ChemistryUniversity of Gdansk, Department of ChemistryUniversity of Gdansk, Department of Chemistry Opioid receptors play the pain control function in the body. Most of the research is carried out to find the most effective analgesic. The earliest analgesic is morphine, however, unfortunately it has many side effects [Mizoguchi H et al. 2003 J. Pharmacol Sci. 93 423]. At a later time dermorphin was discovered as another potent analgesic [Montecucchi P C et al. 1981 Int. J. Pept. Protein Res. 17 275]. Unfortunately, this peptide is not resistant to enzymatic metabolism [Kisara K et al. 1986 Br. J. Pharmacol. 87 183; Sasaki Y et al. 1985 Neuropeptides 5 391]. The objective of this study is to search for new opioid analgesics by investigation of interactions between dermorphin analogs and the µ-opioid receptor using molecular modeling methods. MOPR (µ-Opioid Peptide Receptor) complexes with several ligands (with known biological activity) were modeled to explain how the structure of the complex was related to the biological activity. The investigated dermorphin analogs containing [DMT1, D-Arg2] (especially tetrapeptides) may become a good alternative for the currently used analgesics. https://journal.mostwiedzy.pl/TASKQuarterly/article/view/1895molecular modelingopioid receptorsdefmorphinmolecular dockingdrug design |
| spellingShingle | AGNIESZKA KARCZYŃSKA BARTŁOMIEJ ZABOROWSKI MAGDALENA ŚLUSARZ INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR TASK Quarterly molecular modeling opioid receptors defmorphin molecular docking drug design |
| title | INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR |
| title_full | INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR |
| title_fullStr | INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR |
| title_full_unstemmed | INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR |
| title_short | INVESTIGATION OF INTERACTIONS BETWEEN DERMORPHIN ANALOGS AND µ-OPIOID RECEPTOR |
| title_sort | investigation of interactions between dermorphin analogs and µ opioid receptor |
| topic | molecular modeling opioid receptors defmorphin molecular docking drug design |
| url | https://journal.mostwiedzy.pl/TASKQuarterly/article/view/1895 |
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