Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

Abstract Background The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). EVs promote intercellular communication, and the EV cargoes [e.g., prote...

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Bibliographic Details
Main Authors: Anastasia Cheng, Dongsic Choi, Maximilien Lora, Dominique Shum-Tim, Janusz Rak, Inés Colmegna
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Stem Cell Research & Therapy
Subjects:
Multipotent mesenchymal stromal cells
MSC
Extracellular vesicles
Exosomes
sEVs
RAB27B
Online Access:https://doi.org/10.1186/s13287-020-02050-6

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