RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer
Abstract Objective LINC01354 has been defined as a tumor driver in several cancers. Nevertheless, whether LINC01354 involves in endometrial cancer (EC) has been little navigated. Thus, the mechanism of LINC01354 was explored in the disease. Methods Measurements of LINC01354, microRNA (miR)-216b and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-01-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11671-021-03640-w |
| _version_ | 1827826312652259328 |
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| author | Yan Zhang Wei Zhao Fei Na Meng Li Shengchun Tong |
| author_facet | Yan Zhang Wei Zhao Fei Na Meng Li Shengchun Tong |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Abstract Objective LINC01354 has been defined as a tumor driver in several cancers. Nevertheless, whether LINC01354 involves in endometrial cancer (EC) has been little navigated. Thus, the mechanism of LINC01354 was explored in the disease. Methods Measurements of LINC01354, microRNA (miR)-216b and kirsten rat sarcoma viral oncogene (KRAS) levels in EC tissues and cells were performed. LINC01354 low expression and miR-216b overexpression vectors were introduced into EC cells (lshikawa), thereby their effects on cell viability, apoptosis, migration and invasion were manifested. Rescue experiments were also carried out by down-regulating LINC01354 and miR-216b spontaneously. Tumorigenesis in vivo was also assessed. The relationships of LINC01354/miR-216b/KRAS were analyzed. Results Increased LINC01354 and KRAS and reduced miR-216b levels were measured in EC. Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development. LINC01354 counteracted with miR-216b to target KRAS. Suppression of miR-216b antagonized silenced LINC01354-induced impacts on EC cell development. LINC01354/miR-216b/KRAS axis enhanced tumorigenesis in mice with EC. Conclusion It is testified that silencing LINC01354 inhibits KRAS by up-regulating miR-216b, thereby discouraging cell malignant phenotype in EC. |
| first_indexed | 2024-03-12T03:08:05Z |
| format | Article |
| id | doaj.art-66130ab19d6140ee8cc962b1fe70d0a7 |
| institution | Directory Open Access Journal |
| issn | 1556-276X |
| language | English |
| last_indexed | 2024-03-12T03:08:05Z |
| publishDate | 2022-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-66130ab19d6140ee8cc962b1fe70d0a72023-09-03T14:31:19ZengSpringerOpenNanoscale Research Letters1556-276X2022-01-0117111010.1186/s11671-021-03640-wRETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial CancerYan Zhang0Wei Zhao1Fei Na2Meng Li3Shengchun Tong4Department of Gynecology, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gynecology, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gynecology, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gynecology, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gynecology, The Fourth Affiliated Hospital of China Medical UniversityAbstract Objective LINC01354 has been defined as a tumor driver in several cancers. Nevertheless, whether LINC01354 involves in endometrial cancer (EC) has been little navigated. Thus, the mechanism of LINC01354 was explored in the disease. Methods Measurements of LINC01354, microRNA (miR)-216b and kirsten rat sarcoma viral oncogene (KRAS) levels in EC tissues and cells were performed. LINC01354 low expression and miR-216b overexpression vectors were introduced into EC cells (lshikawa), thereby their effects on cell viability, apoptosis, migration and invasion were manifested. Rescue experiments were also carried out by down-regulating LINC01354 and miR-216b spontaneously. Tumorigenesis in vivo was also assessed. The relationships of LINC01354/miR-216b/KRAS were analyzed. Results Increased LINC01354 and KRAS and reduced miR-216b levels were measured in EC. Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development. LINC01354 counteracted with miR-216b to target KRAS. Suppression of miR-216b antagonized silenced LINC01354-induced impacts on EC cell development. LINC01354/miR-216b/KRAS axis enhanced tumorigenesis in mice with EC. Conclusion It is testified that silencing LINC01354 inhibits KRAS by up-regulating miR-216b, thereby discouraging cell malignant phenotype in EC.https://doi.org/10.1186/s11671-021-03640-wEndometrial cancerLINC01354MicroRNA-216bKirsten rat sarcoma viral oncogeneTumorigenesis |
| spellingShingle | Yan Zhang Wei Zhao Fei Na Meng Li Shengchun Tong RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer Nanoscale Research Letters Endometrial cancer LINC01354 MicroRNA-216b Kirsten rat sarcoma viral oncogene Tumorigenesis |
| title | RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer |
| title_full | RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer |
| title_fullStr | RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer |
| title_full_unstemmed | RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer |
| title_short | RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer |
| title_sort | retracted article linc01354 microrna 216b kras axis promotes the occurrence and metastasis of endometrial cancer |
| topic | Endometrial cancer LINC01354 MicroRNA-216b Kirsten rat sarcoma viral oncogene Tumorigenesis |
| url | https://doi.org/10.1186/s11671-021-03640-w |
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