心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析
Abstract Background Cardiometabolic comorbidities have been associated with a higher risk of COVID‐19 severity and mortality, but more investigations are needed to determine which comorbidity is more detrimental. Methods Embase, Emcare, and MEDLINE were searched systematically for prospective and re...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13445 |
| _version_ | 1797465774000963584 |
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| author | Alina Binbin Li Bo Yang Yufei Li Rachel Huynh Samuel Shim Kenneth Lo Jie Li Andrew Zullo Wen‐Chih Wu Simin Liu |
| author_facet | Alina Binbin Li Bo Yang Yufei Li Rachel Huynh Samuel Shim Kenneth Lo Jie Li Andrew Zullo Wen‐Chih Wu Simin Liu |
| author_sort | Alina Binbin Li |
| collection | DOAJ |
| description | Abstract Background Cardiometabolic comorbidities have been associated with a higher risk of COVID‐19 severity and mortality, but more investigations are needed to determine which comorbidity is more detrimental. Methods Embase, Emcare, and MEDLINE were searched systematically for prospective and retrospective studies assessing the associations of cardiometabolic risk factors and COVID‐19 outcomes of hospitalization, severity, and mortality among COVID‐19‐diagnosed patients. Literature search was performed from first publication to May 19, 2021. Study quality was assessed by the Newcastle‐Ottawa Scale. Results From the literature search, 301 studies suggested that all included cardiometabolic risk factors were associated with a higher risk of COVID‐19 hospitalization, severity, and mortality, except that overweight was associated with a decreased risk of mortality (relative risk [RR] 0.88; 95% CI, 0.80–0.98). Patients with diabetes (RR 1.46; 95% CI, 1.45–1.47) were most likely to be hospitalized; patients with heart failure had the highest risk for severe COVID‐19 outcomes (RR 1.89; 95% CI, 1.71–2.09); while patients with stroke were most susceptible to overall mortality (RR 1.99; 95% CI, 1.90–2.08). In the network meta‐analysis, cerebrovascular disease had the highest impact (RR 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors. For different combinations of risk factors, cardiovascular disease and diabetes combined (RR 6.98; 95% CI, 5.28–9.22) was more detrimental than others. Conclusions Considering the high prevalence of cardiometabolic comorbidities and risk of all severe outcomes, patients with cardiometabolic comorbidities should be prioritized in vaccination and treatment development of COVID‐19. |
| first_indexed | 2024-03-09T18:27:22Z |
| format | Article |
| id | doaj.art-6615aafe8e664823a8504a027092177d |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-03-09T18:27:22Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-6615aafe8e664823a8504a027092177d2023-11-24T07:49:57ZengWileyJournal of Diabetes1753-03931753-04072023-11-01151196897710.1111/1753-0407.13445心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析Alina Binbin Li0Bo Yang1Yufei Li2Rachel Huynh3Samuel Shim4Kenneth Lo5Jie Li6Andrew Zullo7Wen‐Chih Wu8Simin Liu9Department of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USACentre for Global Cardiometabolic Health, Departments of Epidemiology, Medicine, and Surgery Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USADepartment of Epidemiology, School of Public Health Brown University Providence Rhode Island USAAbstract Background Cardiometabolic comorbidities have been associated with a higher risk of COVID‐19 severity and mortality, but more investigations are needed to determine which comorbidity is more detrimental. Methods Embase, Emcare, and MEDLINE were searched systematically for prospective and retrospective studies assessing the associations of cardiometabolic risk factors and COVID‐19 outcomes of hospitalization, severity, and mortality among COVID‐19‐diagnosed patients. Literature search was performed from first publication to May 19, 2021. Study quality was assessed by the Newcastle‐Ottawa Scale. Results From the literature search, 301 studies suggested that all included cardiometabolic risk factors were associated with a higher risk of COVID‐19 hospitalization, severity, and mortality, except that overweight was associated with a decreased risk of mortality (relative risk [RR] 0.88; 95% CI, 0.80–0.98). Patients with diabetes (RR 1.46; 95% CI, 1.45–1.47) were most likely to be hospitalized; patients with heart failure had the highest risk for severe COVID‐19 outcomes (RR 1.89; 95% CI, 1.71–2.09); while patients with stroke were most susceptible to overall mortality (RR 1.99; 95% CI, 1.90–2.08). In the network meta‐analysis, cerebrovascular disease had the highest impact (RR 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors. For different combinations of risk factors, cardiovascular disease and diabetes combined (RR 6.98; 95% CI, 5.28–9.22) was more detrimental than others. Conclusions Considering the high prevalence of cardiometabolic comorbidities and risk of all severe outcomes, patients with cardiometabolic comorbidities should be prioritized in vaccination and treatment development of COVID‐19.https://doi.org/10.1111/1753-0407.13445心血管代谢危险因素2019冠状病毒病网络meta分析 |
| spellingShingle | Alina Binbin Li Bo Yang Yufei Li Rachel Huynh Samuel Shim Kenneth Lo Jie Li Andrew Zullo Wen‐Chih Wu Simin Liu 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 Journal of Diabetes 心血管代谢危险因素 2019冠状病毒病 网络meta分析 |
| title | 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 |
| title_full | 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 |
| title_fullStr | 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 |
| title_full_unstemmed | 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 |
| title_short | 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析 |
| title_sort | 心血管代谢危险因素与covid 19严重程度关联的网络荟萃分析 |
| topic | 心血管代谢危险因素 2019冠状病毒病 网络meta分析 |
| url | https://doi.org/10.1111/1753-0407.13445 |
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