Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India
Introduction: Dengue is the most common mosquito borne arboviral infection in India, and it has become endemic in India with consistent episodes. Dengue is an acute febrile illness caused by Dengue Virus (DENV-1, DENV-2, DENV-3, DENV-4), an arthropod of family Flaviviridae, transmitted through t...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15239/50602_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA_NC_PB(AG_KM)_PN(KM).pdf |
| _version_ | 1819136156151840768 |
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| author | HARI OM TRIVEDI Asim Kumar Singh Mukesh Kumar Singh |
| author_facet | HARI OM TRIVEDI Asim Kumar Singh Mukesh Kumar Singh |
| author_sort | HARI OM TRIVEDI |
| collection | DOAJ |
| description | Introduction: Dengue is the most common mosquito borne
arboviral infection in India, and it has become endemic in India with
consistent episodes. Dengue is an acute febrile illness caused by
Dengue Virus (DENV-1, DENV-2, DENV-3, DENV-4), an arthropod
of family Flaviviridae, transmitted through the bite of female
Aedes aegypti mosquitoes. Although, dengue is more prevalent
in humans but also it may sometimes be seen in monkeys. The
only animals to be affected when bitten by a mosquito, infected
with dengue fever are monkeys other animals do not carry or
spread dengue. Patient presents with hyperthermia, headache,
severe joint and muscle pain, fatigue and skin rashes. Neurological
manifestation in sever dengue results from multiorgan dysfunction
due to cerebral edema, haemorrhage due to vascular leak,
cerebral hypoperfusion, and electrolyte disturbances.
Aim: To study serological markers with association of platelet
count and trend of DENV infection with seasonal variation.
Materials and Methods: The present retrospective study was
conducted for a period of two years in Heritage Institute of
Medical Sciences (HIMS), Varanasi, Uttar Pradesh, India, from
January 2017 to December 2018. Blood samples were collected
for 2140 suspected dengue patients. Out of the serologically
positive cases, serological confirmation and platelet count was
done for dengue infection. Data was presented as percentages.
Results: Total 2140 suspected cases were admitted and out
of them 199 (9.3%) were found to be seropositive for dengue
infection. Non structural protein 1 (NS1) positive cases out of
which total seropositive cases were reported to be 127 (63.81%)
and 147 (73.86%) cases were positive for NS1 antigen either
alone or along with antibody. Out of the total 199 positive cases
thrombocytopenia was observed in 126 (63.31%) cases. Positive
cases which were under 15 years of age were reported to be
92 (46.23%).
Conclusion: The study concludes that NS1 antigen and IgMIgG antibody consideration in the diagnosis of dengue infection
builds the opportunity of early diagnosis so as to keep away the
complications significantly |
| first_indexed | 2024-12-22T10:30:30Z |
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| id | doaj.art-66160ddd8f064ab2b75c6751f981fff5 |
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| language | English |
| last_indexed | 2024-12-22T10:30:30Z |
| publishDate | 2021-08-01 |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-66160ddd8f064ab2b75c6751f981fff52022-12-21T18:29:21ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158DC07DC1010.7860/JCDR/2021/50602.15239Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, IndiaHARI OM TRIVEDI0Asim Kumar Singh1 Mukesh Kumar Singh2Student, Department of Microbiology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, IndiaAssociate Professor, Department of Microbiology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India.Assistant Professor, Department of Microbiology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India.Introduction: Dengue is the most common mosquito borne arboviral infection in India, and it has become endemic in India with consistent episodes. Dengue is an acute febrile illness caused by Dengue Virus (DENV-1, DENV-2, DENV-3, DENV-4), an arthropod of family Flaviviridae, transmitted through the bite of female Aedes aegypti mosquitoes. Although, dengue is more prevalent in humans but also it may sometimes be seen in monkeys. The only animals to be affected when bitten by a mosquito, infected with dengue fever are monkeys other animals do not carry or spread dengue. Patient presents with hyperthermia, headache, severe joint and muscle pain, fatigue and skin rashes. Neurological manifestation in sever dengue results from multiorgan dysfunction due to cerebral edema, haemorrhage due to vascular leak, cerebral hypoperfusion, and electrolyte disturbances. Aim: To study serological markers with association of platelet count and trend of DENV infection with seasonal variation. Materials and Methods: The present retrospective study was conducted for a period of two years in Heritage Institute of Medical Sciences (HIMS), Varanasi, Uttar Pradesh, India, from January 2017 to December 2018. Blood samples were collected for 2140 suspected dengue patients. Out of the serologically positive cases, serological confirmation and platelet count was done for dengue infection. Data was presented as percentages. Results: Total 2140 suspected cases were admitted and out of them 199 (9.3%) were found to be seropositive for dengue infection. Non structural protein 1 (NS1) positive cases out of which total seropositive cases were reported to be 127 (63.81%) and 147 (73.86%) cases were positive for NS1 antigen either alone or along with antibody. Out of the total 199 positive cases thrombocytopenia was observed in 126 (63.31%) cases. Positive cases which were under 15 years of age were reported to be 92 (46.23%). Conclusion: The study concludes that NS1 antigen and IgMIgG antibody consideration in the diagnosis of dengue infection builds the opportunity of early diagnosis so as to keep away the complications significantlyhttps://jcdr.net/articles/PDF/15239/50602_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA_NC_PB(AG_KM)_PN(KM).pdfmosquito borne arboviral infectionnon structural protein 1 antigenseropositivityviral infection |
| spellingShingle | HARI OM TRIVEDI Asim Kumar Singh Mukesh Kumar Singh Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India Journal of Clinical and Diagnostic Research mosquito borne arboviral infection non structural protein 1 antigen seropositivity viral infection |
| title | Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India |
| title_full | Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India |
| title_fullStr | Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India |
| title_full_unstemmed | Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India |
| title_short | Trend of Dengue Virus Infection with Seasonal Variation at HIMS, Varanasi, Uttar Pradesh, India |
| title_sort | trend of dengue virus infection with seasonal variation at hims varanasi uttar pradesh india |
| topic | mosquito borne arboviral infection non structural protein 1 antigen seropositivity viral infection |
| url | https://jcdr.net/articles/PDF/15239/50602_CE[Ra1]_F[SK]_PF1(AG_OM)_PFA_NC_PB(AG_KM)_PN(KM).pdf |
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