An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases
Background and AimsMucinous colorectal cancer has traditionally been associated with high rates of recurrence and poor long-term survival. There is limited published data on outcomes for patients undergoing liver resection for metastatic mucinous colorectal cancer. The aim of this study was to compa...
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| Format: | Article |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.821159/full |
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| author | Ian S. Reynolds Ian S. Reynolds Paul M. Cromwell Éanna J. Ryan Erinn McGrath Rory Kennelly Ronan Ryan Niall Swan Kieran Sheahan Des C. Winter Emir Hoti |
| author_facet | Ian S. Reynolds Ian S. Reynolds Paul M. Cromwell Éanna J. Ryan Erinn McGrath Rory Kennelly Ronan Ryan Niall Swan Kieran Sheahan Des C. Winter Emir Hoti |
| author_sort | Ian S. Reynolds |
| collection | DOAJ |
| description | Background and AimsMucinous colorectal cancer has traditionally been associated with high rates of recurrence and poor long-term survival. There is limited published data on outcomes for patients undergoing liver resection for metastatic mucinous colorectal cancer. The aim of this study was to compare the clinicopathological outcomes for patients with mucinous colorectal cancer liver metastases (CRCLM) undergoing liver resection to a matched group of patients with adenocarcinoma not otherwise specified (NOS) and to evaluate the accurary of preoperative magnetic resonance imaging (MRI) at detecting the presence of mucin in liver metastases.Materials and MethodsPatients with mucinous CRCLM undergoing liver resection were matched 1:3 to patients with adenocarcinoma NOS CRCLM. Clinicopathological data from the primary tumour and metastatic lesion were collected and compared between the groups. Hepatic recurrence-free, disease-free and overall survival were compared between the groups. The ability of preoperative MRI to detect mucin in CRCLM was also evaluated.ResultsA total of 25 patients with mucinous CRCLM underwent surgery over the 12-year period and were matched to 75 patients with adenocarcinoma NOS. Clinicopathological findings were similar between the groups. Resection of mucinous CRCLM was feasible and safe with similar levels of morbidity to adenocarcinoma NOS. There were no differences identified in hepatic recurrence-free (p=0.85), disease-free (p=0.25) and overall survival (p=0.98) between the groups. MRI had a sensitivity of 31.3% in detecting the presence of mucin in CRCLM.ConclusionPatients with mucinous CRCLM in this study had similar outcomes to patients with adenocarcinoma NOS. Based on our findings, histological subtype should not be taken into account when deciding on resectability of CRCLM. |
| first_indexed | 2024-12-24T00:33:58Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-24T00:33:58Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-66176090496f4af78985019f7a8d712e2022-12-21T17:24:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-02-011210.3389/fonc.2022.821159821159An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver MetastasesIan S. Reynolds0Ian S. Reynolds1Paul M. Cromwell2Éanna J. Ryan3Erinn McGrath4Rory Kennelly5Ronan Ryan6Niall Swan7Kieran Sheahan8Des C. Winter9Emir Hoti10Department of Hepatobiliary and Liver Transplant Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Colorectal Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Hepatobiliary and Liver Transplant Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Colorectal Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Histopathology, St Vincent’s University Hospital, Dublin, IrelandDepartment of Colorectal Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Radiology, St Vincent’s University Hospital, Dublin, IrelandDepartment of Histopathology, St Vincent’s University Hospital, Dublin, IrelandDepartment of Histopathology, St Vincent’s University Hospital, Dublin, IrelandDepartment of Colorectal Surgery, St Vincent’s University Hospital, Dublin, IrelandDepartment of Hepatobiliary and Liver Transplant Surgery, St Vincent’s University Hospital, Dublin, IrelandBackground and AimsMucinous colorectal cancer has traditionally been associated with high rates of recurrence and poor long-term survival. There is limited published data on outcomes for patients undergoing liver resection for metastatic mucinous colorectal cancer. The aim of this study was to compare the clinicopathological outcomes for patients with mucinous colorectal cancer liver metastases (CRCLM) undergoing liver resection to a matched group of patients with adenocarcinoma not otherwise specified (NOS) and to evaluate the accurary of preoperative magnetic resonance imaging (MRI) at detecting the presence of mucin in liver metastases.Materials and MethodsPatients with mucinous CRCLM undergoing liver resection were matched 1:3 to patients with adenocarcinoma NOS CRCLM. Clinicopathological data from the primary tumour and metastatic lesion were collected and compared between the groups. Hepatic recurrence-free, disease-free and overall survival were compared between the groups. The ability of preoperative MRI to detect mucin in CRCLM was also evaluated.ResultsA total of 25 patients with mucinous CRCLM underwent surgery over the 12-year period and were matched to 75 patients with adenocarcinoma NOS. Clinicopathological findings were similar between the groups. Resection of mucinous CRCLM was feasible and safe with similar levels of morbidity to adenocarcinoma NOS. There were no differences identified in hepatic recurrence-free (p=0.85), disease-free (p=0.25) and overall survival (p=0.98) between the groups. MRI had a sensitivity of 31.3% in detecting the presence of mucin in CRCLM.ConclusionPatients with mucinous CRCLM in this study had similar outcomes to patients with adenocarcinoma NOS. Based on our findings, histological subtype should not be taken into account when deciding on resectability of CRCLM.https://www.frontiersin.org/articles/10.3389/fonc.2022.821159/fullcolorectal cancercolorectal cancer liver metastasismucinous colorectal cancerliver resectionsurgical oncology, mucinous colorectal cancer liver metastasis |
| spellingShingle | Ian S. Reynolds Ian S. Reynolds Paul M. Cromwell Éanna J. Ryan Erinn McGrath Rory Kennelly Ronan Ryan Niall Swan Kieran Sheahan Des C. Winter Emir Hoti An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases Frontiers in Oncology colorectal cancer colorectal cancer liver metastasis mucinous colorectal cancer liver resection surgical oncology, mucinous colorectal cancer liver metastasis |
| title | An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases |
| title_full | An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases |
| title_fullStr | An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases |
| title_full_unstemmed | An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases |
| title_short | An Analysis of Clinicopathological Outcomes and the Utility of Preoperative MRI for Patients Undergoing Resection of Mucinous and Non-Mucinous Colorectal Cancer Liver Metastases |
| title_sort | analysis of clinicopathological outcomes and the utility of preoperative mri for patients undergoing resection of mucinous and non mucinous colorectal cancer liver metastases |
| topic | colorectal cancer colorectal cancer liver metastasis mucinous colorectal cancer liver resection surgical oncology, mucinous colorectal cancer liver metastasis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.821159/full |
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