Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome
A 2-year-old girl started to wobble without any specific triggers, so the patient was admitted to our hospital's pediatric department. The entire cerebellum showed severe atrophy on MRI and much lower uptake than that in the cerebral cortex on perfusion SPECT. The diagnosis of opsoclonus-myoclo...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-01-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
| Subjects: | |
| Online Access: | https://aojnmb.mums.ac.ir/article_20938_eaf9b24921cd88510ca08caa6dfe6ae8.pdf |
| _version_ | 1798005398344564736 |
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| author | Junki Takenaka Kenji Hirata Shiro Watanabe Hideaki Shiraishi Kudo Kohsuke |
| author_facet | Junki Takenaka Kenji Hirata Shiro Watanabe Hideaki Shiraishi Kudo Kohsuke |
| author_sort | Junki Takenaka |
| collection | DOAJ |
| description | A 2-year-old girl started to wobble without any specific triggers, so the patient was admitted to our hospital's pediatric department. The entire cerebellum showed severe atrophy on MRI and much lower uptake than that in the cerebral cortex on perfusion SPECT. The diagnosis of opsoclonus-myoclonus syndrome (OMS) was suspected. MRI visualized a small mass behind the inferior vena cava. Although its uptake on I-123 MIBG scintigraphy was inconclusive, the mass was surgically removed, and the diagnosis of neuroblastoma was pathologically confirmed. OMS is one of the paraneoplastic neurological syndromes with cerebellar ataxia, myoclonus of the trunk and extremities, and opsoclonus as its main symptoms. Approximately 50% of children cases with OMS are associated with neuroblastoma. The prognosis for neuroblastoma itself with OMS is relatively good, but the neurological prognosis is very poor. If there is decreased blood flow in the cerebellum of an infant, it may be necessary to search for neuroblastoma. |
| first_indexed | 2024-04-11T12:38:54Z |
| format | Article |
| id | doaj.art-6618741af8fb4a93a651f59b8d5c6464 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-04-11T12:38:54Z |
| publishDate | 2023-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-6618741af8fb4a93a651f59b8d5c64642022-12-22T04:23:33ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262023-01-01111939610.22038/aojnmb.2022.65833.145920938Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndromeJunki Takenaka0Kenji Hirata1Shiro Watanabe2Hideaki Shiraishi3Kudo Kohsuke4Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Sapporo, JapanDepartment of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, JapanA 2-year-old girl started to wobble without any specific triggers, so the patient was admitted to our hospital's pediatric department. The entire cerebellum showed severe atrophy on MRI and much lower uptake than that in the cerebral cortex on perfusion SPECT. The diagnosis of opsoclonus-myoclonus syndrome (OMS) was suspected. MRI visualized a small mass behind the inferior vena cava. Although its uptake on I-123 MIBG scintigraphy was inconclusive, the mass was surgically removed, and the diagnosis of neuroblastoma was pathologically confirmed. OMS is one of the paraneoplastic neurological syndromes with cerebellar ataxia, myoclonus of the trunk and extremities, and opsoclonus as its main symptoms. Approximately 50% of children cases with OMS are associated with neuroblastoma. The prognosis for neuroblastoma itself with OMS is relatively good, but the neurological prognosis is very poor. If there is decreased blood flow in the cerebellum of an infant, it may be necessary to search for neuroblastoma.https://aojnmb.mums.ac.ir/article_20938_eaf9b24921cd88510ca08caa6dfe6ae8.pdfopsoclonus-myoclonus syndromeneuroblastomabrain perfusion spect |
| spellingShingle | Junki Takenaka Kenji Hirata Shiro Watanabe Hideaki Shiraishi Kudo Kohsuke Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome Asia Oceania Journal of Nuclear Medicine and Biology opsoclonus-myoclonus syndrome neuroblastoma brain perfusion spect |
| title | Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome |
| title_full | Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome |
| title_fullStr | Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome |
| title_full_unstemmed | Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome |
| title_short | Neuroblastoma-related severe hypoperfusion in the cerebellum of an infant: A case of opsoclonus-myoclonus syndrome |
| title_sort | neuroblastoma related severe hypoperfusion in the cerebellum of an infant a case of opsoclonus myoclonus syndrome |
| topic | opsoclonus-myoclonus syndrome neuroblastoma brain perfusion spect |
| url | https://aojnmb.mums.ac.ir/article_20938_eaf9b24921cd88510ca08caa6dfe6ae8.pdf |
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