A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Abstract Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism and each of the 439 proteins. 47,536...

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Bibliographic Details
Main Authors: Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Molecular Brain
Subjects:
Polygenic risk score
Protein quantitative trait loci
Neuroticism
Depression
Anxiety
Online Access:https://doi.org/10.1186/s13041-022-00954-3

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