Research progress on the role of extracellular vesicles in neurodegenerative diseases
Abstract Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into disease-related research, but few breakthroughs have been made in diagnostic and...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-09-01
|
| Series: | Translational Neurodegeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40035-023-00375-9 |
| _version_ | 1797556928452231168 |
|---|---|
| author | Zhengzhe Li Xiaoling Wang Xiaoxing Wang Xiaomei Yi Yin Kwan Wong Jiyang Wu Fangfang Xie Die Hu Qi Wang Jigang Wang Tianyu Zhong |
| author_facet | Zhengzhe Li Xiaoling Wang Xiaoxing Wang Xiaomei Yi Yin Kwan Wong Jiyang Wu Fangfang Xie Die Hu Qi Wang Jigang Wang Tianyu Zhong |
| author_sort | Zhengzhe Li |
| collection | DOAJ |
| description | Abstract Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into disease-related research, but few breakthroughs have been made in diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are heterogeneous cell-derived membrane structures that arise from the endosomal system or are directly separated from the plasma membrane. EVs contain many biomolecules, including proteins, nucleic acids, and lipids, which can be transferred between different cells, tissues, or organs, thereby regulating cross-organ communication between cells during normal and pathological processes. Recently, EVs have been shown to participate in various aspects of neurodegenerative diseases. Abnormal secretion and levels of EVs are closely related to the pathogenesis of neurodegenerative diseases and contribute to disease progression. Numerous studies have proposed EVs as therapeutic targets or biomarkers for neurodegenerative diseases. In this review, we summarize and discuss the advanced research progress on EVs in the pathological processes of several neurodegenerative diseases. Moreover, we outline the latest research on the roles of EVs in neurodegenerative diseases and their therapeutic potential for the diseases. |
| first_indexed | 2024-03-10T17:08:46Z |
| format | Article |
| id | doaj.art-6619a5e7f27646f7a302fb174f94ead1 |
| institution | Directory Open Access Journal |
| issn | 2047-9158 |
| language | English |
| last_indexed | 2024-03-10T17:08:46Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Translational Neurodegeneration |
| spelling | doaj.art-6619a5e7f27646f7a302fb174f94ead12023-11-20T10:42:28ZengBMCTranslational Neurodegeneration2047-91582023-09-0112111910.1186/s40035-023-00375-9Research progress on the role of extracellular vesicles in neurodegenerative diseasesZhengzhe Li0Xiaoling Wang1Xiaoxing Wang2Xiaomei Yi3Yin Kwan Wong4Jiyang Wu5Fangfang Xie6Die Hu7Qi Wang8Jigang Wang9Tianyu Zhong10The First School of Clinical Medicine, Gannan Medical UniversityLaboratory Medicine, First Affiliated Hospital of Gannan Medical UniversityThe First School of Clinical Medicine, Gannan Medical UniversityThe First School of Clinical Medicine, Gannan Medical UniversityDepartment of Nephrology, Shenzhen Key Laboratory of Kidney Diseases, and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and TechnologyThe First School of Clinical Medicine, Gannan Medical UniversityLaboratory Medicine, First Affiliated Hospital of Gannan Medical UniversityLaboratory Medicine, First Affiliated Hospital of Gannan Medical UniversityThe First School of Clinical Medicine, Gannan Medical UniversityLaboratory Medicine, First Affiliated Hospital of Gannan Medical UniversityThe First School of Clinical Medicine, Gannan Medical UniversityAbstract Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, affect millions of people worldwide. Tremendous efforts have been put into disease-related research, but few breakthroughs have been made in diagnostic and therapeutic approaches. Extracellular vesicles (EVs) are heterogeneous cell-derived membrane structures that arise from the endosomal system or are directly separated from the plasma membrane. EVs contain many biomolecules, including proteins, nucleic acids, and lipids, which can be transferred between different cells, tissues, or organs, thereby regulating cross-organ communication between cells during normal and pathological processes. Recently, EVs have been shown to participate in various aspects of neurodegenerative diseases. Abnormal secretion and levels of EVs are closely related to the pathogenesis of neurodegenerative diseases and contribute to disease progression. Numerous studies have proposed EVs as therapeutic targets or biomarkers for neurodegenerative diseases. In this review, we summarize and discuss the advanced research progress on EVs in the pathological processes of several neurodegenerative diseases. Moreover, we outline the latest research on the roles of EVs in neurodegenerative diseases and their therapeutic potential for the diseases.https://doi.org/10.1186/s40035-023-00375-9Extracellular vesicleNeurodegenerative diseaseCentral nervous systemNeurodegenerationPathogenesisBiomarker |
| spellingShingle | Zhengzhe Li Xiaoling Wang Xiaoxing Wang Xiaomei Yi Yin Kwan Wong Jiyang Wu Fangfang Xie Die Hu Qi Wang Jigang Wang Tianyu Zhong Research progress on the role of extracellular vesicles in neurodegenerative diseases Translational Neurodegeneration Extracellular vesicle Neurodegenerative disease Central nervous system Neurodegeneration Pathogenesis Biomarker |
| title | Research progress on the role of extracellular vesicles in neurodegenerative diseases |
| title_full | Research progress on the role of extracellular vesicles in neurodegenerative diseases |
| title_fullStr | Research progress on the role of extracellular vesicles in neurodegenerative diseases |
| title_full_unstemmed | Research progress on the role of extracellular vesicles in neurodegenerative diseases |
| title_short | Research progress on the role of extracellular vesicles in neurodegenerative diseases |
| title_sort | research progress on the role of extracellular vesicles in neurodegenerative diseases |
| topic | Extracellular vesicle Neurodegenerative disease Central nervous system Neurodegeneration Pathogenesis Biomarker |
| url | https://doi.org/10.1186/s40035-023-00375-9 |
| work_keys_str_mv | AT zhengzheli researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT xiaolingwang researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT xiaoxingwang researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT xiaomeiyi researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT yinkwanwong researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT jiyangwu researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT fangfangxie researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT diehu researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT qiwang researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT jigangwang researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases AT tianyuzhong researchprogressontheroleofextracellularvesiclesinneurodegenerativediseases |