Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models
Broccoli sprouts are a super vegetable; however, they have possible negative effects on thyroid function, which is especially important for patients with hypothyroidism. As the data on this issue are scarce, this study aimed to determine the safety and possible beneficial effect of broccoli sprouts...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/20/2750 |
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| author | Paweł Paśko Paweł Zagrodzki Krzysztof Okoń Ewelina Prochownik Mirosław Krośniak Agnieszka Galanty |
| author_facet | Paweł Paśko Paweł Zagrodzki Krzysztof Okoń Ewelina Prochownik Mirosław Krośniak Agnieszka Galanty |
| author_sort | Paweł Paśko |
| collection | DOAJ |
| description | Broccoli sprouts are a super vegetable; however, they have possible negative effects on thyroid function, which is especially important for patients with hypothyroidism. As the data on this issue are scarce, this study aimed to determine the safety and possible beneficial effect of broccoli sprouts both in vitro and in vivo. The in vitro model comprised the evaluation of the impact of broccoli sprouts on normal and neoplastic thyroid cells and the determination of their anti-inflammatory and antioxidant (IL-6, TNF-alpha, NO, and SOD) potential in macrophages. The in vivo model concerned the histopathological analysis of thyroid glands in healthy rats and rats with hypothyroidism (induced by iodine deficiency or sulfadimethoxine ingestion) fed with broccoli sprouts. The results of our study indicated that broccoli sprouts decreased the viability of thyroid cancer cells and prevented inflammation. The results also confirmed the satisfactory safety profile of the sprouts, both in vitro and in vivo; however, a further in-depth evaluation of this problem is still needed. Information on the influence of brassica vegetables on thyroid function is of great importance in terms of public health, particularly when taking into account that the risk of iodine deficiency, hypothyroidism, and thyroid cancer in the global population is still increasing. |
| first_indexed | 2024-03-09T19:33:38Z |
| format | Article |
| id | doaj.art-661d229242894d068364da7552849fcb |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T19:33:38Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-661d229242894d068364da7552849fcb2023-11-24T02:04:46ZengMDPI AGPlants2223-77472022-10-011120275010.3390/plants11202750Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo ModelsPaweł Paśko0Paweł Zagrodzki1Krzysztof Okoń2Ewelina Prochownik3Mirosław Krośniak4Agnieszka Galanty5Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pathomorphology, Jagiellonian University Medical College, Grzegórzecka 16, 31-531 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pharmacognosy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandBroccoli sprouts are a super vegetable; however, they have possible negative effects on thyroid function, which is especially important for patients with hypothyroidism. As the data on this issue are scarce, this study aimed to determine the safety and possible beneficial effect of broccoli sprouts both in vitro and in vivo. The in vitro model comprised the evaluation of the impact of broccoli sprouts on normal and neoplastic thyroid cells and the determination of their anti-inflammatory and antioxidant (IL-6, TNF-alpha, NO, and SOD) potential in macrophages. The in vivo model concerned the histopathological analysis of thyroid glands in healthy rats and rats with hypothyroidism (induced by iodine deficiency or sulfadimethoxine ingestion) fed with broccoli sprouts. The results of our study indicated that broccoli sprouts decreased the viability of thyroid cancer cells and prevented inflammation. The results also confirmed the satisfactory safety profile of the sprouts, both in vitro and in vivo; however, a further in-depth evaluation of this problem is still needed. Information on the influence of brassica vegetables on thyroid function is of great importance in terms of public health, particularly when taking into account that the risk of iodine deficiency, hypothyroidism, and thyroid cancer in the global population is still increasing.https://www.mdpi.com/2223-7747/11/20/2750broccoli sproutsthyroidcancerhypothyroidismrats |
| spellingShingle | Paweł Paśko Paweł Zagrodzki Krzysztof Okoń Ewelina Prochownik Mirosław Krośniak Agnieszka Galanty Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models Plants broccoli sprouts thyroid cancer hypothyroidism rats |
| title | Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models |
| title_full | Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models |
| title_fullStr | Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models |
| title_full_unstemmed | Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models |
| title_short | Broccoli Sprouts and Their Influence on Thyroid Function in Different In Vitro and In Vivo Models |
| title_sort | broccoli sprouts and their influence on thyroid function in different in vitro and in vivo models |
| topic | broccoli sprouts thyroid cancer hypothyroidism rats |
| url | https://www.mdpi.com/2223-7747/11/20/2750 |
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