Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in <i>db/db</i> Mice

Characterization of the Aquaporin-9 Inhibitor RG100204 In Vitro and in <i>db/db</i> Mice

Aquaporin-9 (AQP9) is a facilitator of glycerol and other small neutral solute transmembrane diffusion. Identification of specific inhibitors for aquaporin family proteins has been difficult, due to high sequence similarity between the 13 human isoforms, and due to the limited channel surface areas...

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Bibliographic Details
Main Authors: Marilina Florio, Angelica Engfors, Patrizia Gena, Jessica Larsson, Alessandro Massaro, Stella Timpka, Martina Kvist Reimer, Per Kjellbom, Eric Beitz, Urban Johanson, Michael Rützler, Giuseppe Calamita
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
membrane transport
aquaglyceroporins
metabolic homeostasis
energy balance
glycerol metabolism
gluconeogenesis
Online Access:https://www.mdpi.com/2073-4409/11/19/3118

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