Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect
Cranial bone defects are a major issue in the field of neurosurgery, and improper management of such defects can cause cosmetic issues as well as more serious infections and inflammation. Several strategies exist to manage these defects clinically, but most rely on synthetic materials that are prone...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020301924 |
| _version_ | 1818326347842322432 |
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| author | Takashi Sasaki Kuniyasu Niizuma Atsushi Kanoke Keiko Matsui Shogo Ogita Sherif Rashad Tadashi Kawai Mika Watanabe Hidenori Endo Tetsu Takahashi Shinji Kamakura Teiji Tominaga |
| author_facet | Takashi Sasaki Kuniyasu Niizuma Atsushi Kanoke Keiko Matsui Shogo Ogita Sherif Rashad Tadashi Kawai Mika Watanabe Hidenori Endo Tetsu Takahashi Shinji Kamakura Teiji Tominaga |
| author_sort | Takashi Sasaki |
| collection | DOAJ |
| description | Cranial bone defects are a major issue in the field of neurosurgery, and improper management of such defects can cause cosmetic issues as well as more serious infections and inflammation. Several strategies exist to manage these defects clinically, but most rely on synthetic materials that are prone to complications; thus, a bone regenerative approach would be superior. We tested a material (octacalcium phosphate collagen composite [OCP/Col]) that is known to enhance bone regeneration in a skull defect model in rats. Using a critical-sized rat skull defect model, OCP/Col was implanted in rats with an intact dura or with a partial defect of the dura. The results were compared with those in a no-treatment group over the course of 12 weeks using computed tomographic and histological analysis. OCP/Col enhanced bone regeneration, regardless of whether there was a defect of the dura. OCP/Col can be used to treat skull defects, even when the dura is injured or removed surgically, via bone regeneration with enhanced resorption of OCP/Col, thus limiting the risk of infection greatly. |
| first_indexed | 2024-12-13T11:58:56Z |
| format | Article |
| id | doaj.art-661e324a672a4fc58f4228803d1a1c5b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-13T11:58:56Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-661e324a672a4fc58f4228803d1a1c5b2022-12-21T23:47:08ZengElsevierHeliyon2405-84402020-02-0162e03347Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defectTakashi Sasaki0Kuniyasu Niizuma1Atsushi Kanoke2Keiko Matsui3Shogo Ogita4Sherif Rashad5Tadashi Kawai6Mika Watanabe7Hidenori Endo8Tetsu Takahashi9Shinji Kamakura10Teiji Tominaga11Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurosurgical Engineering and Translational Neuroscience, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan; Corresponding author.Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, JapanDivision of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, JapanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Neurosurgical Engineering and Translational Neuroscience, Tohoku University Graduate School of Medicine, Sendai, JapanDivision of Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka, JapanDepartment of Pathology, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, JapanDivision of Oral and Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, Sendai, JapanBone Regenerative Engineering Laboratory, Graduate School of Biomedical Engineering, Tohoku University, Sendai, JapanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, JapanCranial bone defects are a major issue in the field of neurosurgery, and improper management of such defects can cause cosmetic issues as well as more serious infections and inflammation. Several strategies exist to manage these defects clinically, but most rely on synthetic materials that are prone to complications; thus, a bone regenerative approach would be superior. We tested a material (octacalcium phosphate collagen composite [OCP/Col]) that is known to enhance bone regeneration in a skull defect model in rats. Using a critical-sized rat skull defect model, OCP/Col was implanted in rats with an intact dura or with a partial defect of the dura. The results were compared with those in a no-treatment group over the course of 12 weeks using computed tomographic and histological analysis. OCP/Col enhanced bone regeneration, regardless of whether there was a defect of the dura. OCP/Col can be used to treat skull defects, even when the dura is injured or removed surgically, via bone regeneration with enhanced resorption of OCP/Col, thus limiting the risk of infection greatly.http://www.sciencedirect.com/science/article/pii/S2405844020301924NeuroscienceBiomedical materialsNervous systemNeurosurgeryOrthopedicsTrauma |
| spellingShingle | Takashi Sasaki Kuniyasu Niizuma Atsushi Kanoke Keiko Matsui Shogo Ogita Sherif Rashad Tadashi Kawai Mika Watanabe Hidenori Endo Tetsu Takahashi Shinji Kamakura Teiji Tominaga Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect Heliyon Neuroscience Biomedical materials Nervous system Neurosurgery Orthopedics Trauma |
| title | Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect |
| title_full | Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect |
| title_fullStr | Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect |
| title_full_unstemmed | Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect |
| title_short | Octacalcium phosphate collagen composite (OCP/Col) enhance bone regeneration in a rat model of skull defect with dural defect |
| title_sort | octacalcium phosphate collagen composite ocp col enhance bone regeneration in a rat model of skull defect with dural defect |
| topic | Neuroscience Biomedical materials Nervous system Neurosurgery Orthopedics Trauma |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020301924 |
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