Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers
Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging int...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-06-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2018.00683/full |
| _version_ | 1819089819309965312 |
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| author | Lisa M. Fleischer Rachana D. Somaiya Gregory M. Miller Gregory M. Miller Gregory M. Miller |
| author_facet | Lisa M. Fleischer Rachana D. Somaiya Gregory M. Miller Gregory M. Miller Gregory M. Miller |
| author_sort | Lisa M. Fleischer |
| collection | DOAJ |
| description | Since its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging interest. Here, we review the immunologically-relevant TAAR1 literature and incorporate open-source expression and cancer survival data meta-analyses. We provide strong evidence for TAAR1 expression in the immune system and cancers revealed through NCBI GEO datamining and discuss its regulation in a spectrum of immune cell types as well as in numerous cancers. We discuss connections and logical directions for further study of TAAR1 in immunological function, and its potential role as a mediator or modulator of immune dysregulation, immunological effects of psychostimulant drugs of abuse, and cancer progression. |
| first_indexed | 2024-12-21T22:13:59Z |
| format | Article |
| id | doaj.art-661e3612d704476ebe54078cbbf1f594 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T22:13:59Z |
| publishDate | 2018-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-661e3612d704476ebe54078cbbf1f5942022-12-21T18:48:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-06-01910.3389/fphar.2018.00683342574Review and Meta-Analyses of TAAR1 Expression in the Immune System and CancersLisa M. Fleischer0Rachana D. Somaiya1Gregory M. Miller2Gregory M. Miller3Gregory M. Miller4Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, United StatesDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, United StatesDepartment of Pharmaceutical Sciences, Northeastern University, Boston, MA, United StatesDepartment of Chemical Engineering, Northeastern University, Boston, MA, United StatesCenter for Drug Discovery, Northeastern University, Boston, MA, United StatesSince its discovery in 2001, the major focus of TAAR1 research has been on its role in monoaminergic regulation, drug-induced reward and psychiatric conditions. More recently, TAAR1 expression and functionality in immune system regulation and immune cell activation has become a topic of emerging interest. Here, we review the immunologically-relevant TAAR1 literature and incorporate open-source expression and cancer survival data meta-analyses. We provide strong evidence for TAAR1 expression in the immune system and cancers revealed through NCBI GEO datamining and discuss its regulation in a spectrum of immune cell types as well as in numerous cancers. We discuss connections and logical directions for further study of TAAR1 in immunological function, and its potential role as a mediator or modulator of immune dysregulation, immunological effects of psychostimulant drugs of abuse, and cancer progression.https://www.frontiersin.org/article/10.3389/fphar.2018.00683/fullPBMCplateletgranulocytelymphocyteB-cellT-cell |
| spellingShingle | Lisa M. Fleischer Rachana D. Somaiya Gregory M. Miller Gregory M. Miller Gregory M. Miller Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers Frontiers in Pharmacology PBMC platelet granulocyte lymphocyte B-cell T-cell |
| title | Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers |
| title_full | Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers |
| title_fullStr | Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers |
| title_full_unstemmed | Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers |
| title_short | Review and Meta-Analyses of TAAR1 Expression in the Immune System and Cancers |
| title_sort | review and meta analyses of taar1 expression in the immune system and cancers |
| topic | PBMC platelet granulocyte lymphocyte B-cell T-cell |
| url | https://www.frontiersin.org/article/10.3389/fphar.2018.00683/full |
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