Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon
Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this stud...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/4/689 |
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| author | Geovani de Oliveira Ribeiro Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Fred Julio Costa Monteiro Vanessa S. Morais Roberta Marcatti Marlisson Octavio da S. Rego Emerson Luiz Lima Araújo Steven S. Witkin Fabiola Villanova Xutao Deng Ester Cerdeira Sabino Eric Delwart Élcio Leal Antonio Charlys da Costa |
| author_facet | Geovani de Oliveira Ribeiro Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Fred Julio Costa Monteiro Vanessa S. Morais Roberta Marcatti Marlisson Octavio da S. Rego Emerson Luiz Lima Araújo Steven S. Witkin Fabiola Villanova Xutao Deng Ester Cerdeira Sabino Eric Delwart Élcio Leal Antonio Charlys da Costa |
| author_sort | Geovani de Oliveira Ribeiro |
| collection | DOAJ |
| description | Dengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (<i>n</i> = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region. |
| first_indexed | 2024-03-10T12:16:24Z |
| format | Article |
| id | doaj.art-661e589696e4416ba91d780c41002075 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T12:16:24Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-661e589696e4416ba91d780c410020752023-11-21T15:50:15ZengMDPI AGViruses1999-49152021-04-0113468910.3390/v13040689Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian AmazonGeovani de Oliveira Ribeiro0Danielle Elise Gill1Edcelha Soares D’Athaide Ribeiro2Fred Julio Costa Monteiro3Vanessa S. Morais4Roberta Marcatti5Marlisson Octavio da S. Rego6Emerson Luiz Lima Araújo7Steven S. Witkin8Fabiola Villanova9Xutao Deng10Ester Cerdeira Sabino11Eric Delwart12Élcio Leal13Antonio Charlys da Costa14Laboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belem 66075-000, BrazilDepartamento de Moléstias Infecciosas e Parasitárias and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilPublic Health Laboratory of Amapa—LACEN/AP, Health Surveillance Superintendence of Amapa, Macapa 68905-230, BrazilPublic Health Laboratory of Amapa—LACEN/AP, Health Surveillance Superintendence of Amapa, Macapa 68905-230, BrazilDepartamento de Moléstias Infecciosas e Parasitárias and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilDepartamento de Moléstias Infecciosas e Parasitárias and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilPublic Health Laboratory of Amapa—LACEN/AP, Health Surveillance Superintendence of Amapa, Macapa 68905-230, BrazilGeneral Coordination of Public Health Laboratories of the Strategic Articulation, Department of the Health Surveillance, Secretariat of the Ministry of Health (CGLAB/DAEVS/SVS-MS), Brasília 70719-040, BrazilDepartment of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065-4850, USALaboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belem 66075-000, BrazilVitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417, USADepartamento de Moléstias Infecciosas e Parasitárias and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilVitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 94118-4417, USALaboratório de Diversidade Viral, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belem 66075-000, BrazilDepartamento de Moléstias Infecciosas e Parasitárias and Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-000, BrazilDengue virus (DENV) is a mosquito-borne viral pathogen that plagues many tropical-climate nations around the world, including Brazil. Molecular epidemiology is a growing and increasingly invaluable tool for understanding the dispersal, persistence, and diversity of this impactful virus. In this study, plasma samples (<i>n</i> = 824) from individuals with symptoms consistent with an arboviral febrile illness were analyzed to identity the molecular epidemiological dynamics of DENV circulating in the Brazilian state of Amapá. Twelve DENV type 1 (DENV-1) genomes were identified, which were phylogenetically related to the BR4 lineage of genotype V. Phylodynamics analysis suggested that DENV-1 BR-4 was introduced into Amapá around early 2010, possibly from other states in northern Brazil. We also found unique amino acids substitutions in the DENV-1 envelope and NS5 protein sequences in the Amapá isolates. Characterization of the DENV-1 BR-4 sequences highlights the potential of this new lineage to drive outbreaks of dengue in the Amazon region.https://www.mdpi.com/1999-4915/13/4/689arbovirusflavivirusDenguephylogeographyevolutionBrazil |
| spellingShingle | Geovani de Oliveira Ribeiro Danielle Elise Gill Edcelha Soares D’Athaide Ribeiro Fred Julio Costa Monteiro Vanessa S. Morais Roberta Marcatti Marlisson Octavio da S. Rego Emerson Luiz Lima Araújo Steven S. Witkin Fabiola Villanova Xutao Deng Ester Cerdeira Sabino Eric Delwart Élcio Leal Antonio Charlys da Costa Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon Viruses arbovirus flavivirus Dengue phylogeography evolution Brazil |
| title | Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon |
| title_full | Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon |
| title_fullStr | Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon |
| title_full_unstemmed | Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon |
| title_short | Adaptive Evolution of New Variants of Dengue Virus Serotype 1 Genotype V Circulating in the Brazilian Amazon |
| title_sort | adaptive evolution of new variants of dengue virus serotype 1 genotype v circulating in the brazilian amazon |
| topic | arbovirus flavivirus Dengue phylogeography evolution Brazil |
| url | https://www.mdpi.com/1999-4915/13/4/689 |
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