Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease
Degenerative mitral valvular disease (DMVD) is the most frequent cardiac disease, causing mitral regurgitation (MR) in dogs. The purpose of this study was to compare the ratio of the regurgitant jet area (RJA) to the left atrial area (LAA) (RJA/LAA) with subtracting method to quantify regurgitant vo...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Agriculture, Faisalabad
2016-11-01
|
| Series: | Pakistan Veterinary Journal |
| Subjects: | |
| Online Access: | http://pvj.com.pk/pdf-files/36_4/421-424.pdf |
| _version_ | 1818807640498634752 |
|---|---|
| author | Kursad Turgut1*, Yilmaz Koc2, Hasan Guzelbektes1,3, Amir Naseri1, Mehmet Ege Ince1 and Ismail Sen1 |
| author_facet | Kursad Turgut1*, Yilmaz Koc2, Hasan Guzelbektes1,3, Amir Naseri1, Mehmet Ege Ince1 and Ismail Sen1 |
| author_sort | Kursad Turgut1*, Yilmaz Koc2, Hasan Guzelbektes1,3, Amir Naseri1, Mehmet Ege Ince1 and Ismail Sen1 |
| collection | DOAJ |
| description | Degenerative mitral valvular disease (DMVD) is the most frequent cardiac disease, causing mitral regurgitation (MR) in dogs. The purpose of this study was to compare the ratio of the regurgitant jet area (RJA) to the left atrial area (LAA) (RJA/LAA) with subtracting method to quantify regurgitant volume (RegV) and regurgitant fraction (RF) in asymptomatic Anatolian Shepherd Dogs (ASHs) with DMVD. Thirty-eight ASHs with DMVD were used as experimental group. The control group consisted of 35 healthy ASHs. In 38 ASHs with DMVD (20 B1 dogs and 18 B2 dogs), the severity of MR was assessed by RJA/LAA and subtraction method. No differences were noted between the assays measuring the severity of MR by χ2 analysis. The observed agreement between the assays was 81% for RJA/LAA vs RegV and was 73% for RJA/LAA vs RF, and the kappa statistic values for RJA/LAA vs RegV and for RJA/LAA vs RF were 0.63 (substantial agreement) and 0.50 (moderate agreement), respectively. Our results indicate that each quantification method was valuable to estimate the acuteness of the disease in ASHs with MR and all were in good accordance with the echocardiographic heart size and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) measurements. Therefore, the each of these non-invasive methods may be functional to serially estimate the acuteness of MR in DMVD in order to monitor the progression of disease. Future studies have to evaluate, if these will be useful to anticipate the risk or time of decompensation in asymptomatic dogs. |
| first_indexed | 2024-12-18T19:28:53Z |
| format | Article |
| id | doaj.art-661e6eeb20394401aa7c4068e89cff48 |
| institution | Directory Open Access Journal |
| issn | 0253-8318 2074-7764 |
| language | English |
| last_indexed | 2024-12-18T19:28:53Z |
| publishDate | 2016-11-01 |
| publisher | University of Agriculture, Faisalabad |
| record_format | Article |
| series | Pakistan Veterinary Journal |
| spelling | doaj.art-661e6eeb20394401aa7c4068e89cff482022-12-21T20:55:46ZengUniversity of Agriculture, FaisalabadPakistan Veterinary Journal0253-83182074-77642016-11-01364421424Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve DiseaseKursad Turgut1*, Yilmaz Koc2, Hasan Guzelbektes1,3, Amir Naseri1, Mehmet Ege Ince1 and Ismail Sen101Selcuk University, Faculty of Veterinary Medicine, Department of Internal Medicine; 2Department of Surgery, Konya/Turkey; 3Kyrgyz Turk Manas University, Faculty of Veterinary Medicine, Department of Internal Medicine, Bishkek/KyrgyzstanDegenerative mitral valvular disease (DMVD) is the most frequent cardiac disease, causing mitral regurgitation (MR) in dogs. The purpose of this study was to compare the ratio of the regurgitant jet area (RJA) to the left atrial area (LAA) (RJA/LAA) with subtracting method to quantify regurgitant volume (RegV) and regurgitant fraction (RF) in asymptomatic Anatolian Shepherd Dogs (ASHs) with DMVD. Thirty-eight ASHs with DMVD were used as experimental group. The control group consisted of 35 healthy ASHs. In 38 ASHs with DMVD (20 B1 dogs and 18 B2 dogs), the severity of MR was assessed by RJA/LAA and subtraction method. No differences were noted between the assays measuring the severity of MR by χ2 analysis. The observed agreement between the assays was 81% for RJA/LAA vs RegV and was 73% for RJA/LAA vs RF, and the kappa statistic values for RJA/LAA vs RegV and for RJA/LAA vs RF were 0.63 (substantial agreement) and 0.50 (moderate agreement), respectively. Our results indicate that each quantification method was valuable to estimate the acuteness of the disease in ASHs with MR and all were in good accordance with the echocardiographic heart size and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) measurements. Therefore, the each of these non-invasive methods may be functional to serially estimate the acuteness of MR in DMVD in order to monitor the progression of disease. Future studies have to evaluate, if these will be useful to anticipate the risk or time of decompensation in asymptomatic dogs.http://pvj.com.pk/pdf-files/36_4/421-424.pdfAnatolian shepherd dogCanineCardiacDegenerative mitral valve diseaseQuantification of mitral regurgitation |
| spellingShingle | Kursad Turgut1*, Yilmaz Koc2, Hasan Guzelbektes1,3, Amir Naseri1, Mehmet Ege Ince1 and Ismail Sen1 Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease Pakistan Veterinary Journal Anatolian shepherd dog Canine Cardiac Degenerative mitral valve disease Quantification of mitral regurgitation |
| title | Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease |
| title_full | Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease |
| title_fullStr | Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease |
| title_full_unstemmed | Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease |
| title_short | Quantification of Mitral Regurgitation in Anatolian Shepherd Dogs with Asymptomatic Degenerative Mitral Valve Disease |
| title_sort | quantification of mitral regurgitation in anatolian shepherd dogs with asymptomatic degenerative mitral valve disease |
| topic | Anatolian shepherd dog Canine Cardiac Degenerative mitral valve disease Quantification of mitral regurgitation |
| url | http://pvj.com.pk/pdf-files/36_4/421-424.pdf |
| work_keys_str_mv | AT kursadturgut1yilmazkoc2hasanguzelbektes13amirnaseri1mehmetegeince1andismailsen1 quantificationofmitralregurgitationinanatolianshepherddogswithasymptomaticdegenerativemitralvalvedisease |