An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs
To analyze the relationship between homologous and heterologous serological titers of immunized pigs and their protection statuses against FMD virus challenges, in the present study, the correlation between the virus neutralization titers at 21 and 28 dpv and the protection statuses at 28 dpv agains...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/1/10 |
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| author | Jaejo Kim Seung Heon Lee Ha-Hyun Kim Sung-Ho Shin Sang-Hyun Park Jong-Hyeon Park Choi-Kyu Park |
| author_facet | Jaejo Kim Seung Heon Lee Ha-Hyun Kim Sung-Ho Shin Sang-Hyun Park Jong-Hyeon Park Choi-Kyu Park |
| author_sort | Jaejo Kim |
| collection | DOAJ |
| description | To analyze the relationship between homologous and heterologous serological titers of immunized pigs and their protection statuses against FMD virus challenges, in the present study, the correlation between the virus neutralization titers at 21 and 28 dpv and the protection statuses at 28 dpv against challenge with FMD virus was analyzed using data sets comprising five different combinations of homologous or heterologous challenge experiments in pigs vaccinated with type O (<i>n</i> = 96), A (<i>n</i> = 69), and Asia 1 (<i>n</i> = 74). As a result, the experiments were divided into three groups (21D-1, 21D-2, and 21D-3) in the 21-dpv model and two groups (28D-1 and 28D-2) in the 28-dpv model. Each response curve of groups 21D-1 and 21D-2 in the 21-dpv model was very similar to each curve of groups 28D-1 and 28D-2 in the 28-dpv model, respectively, even though there was an exceptional extra group (21D-3) in the 21-dpv model. The average titers estimating 0.75 probability of protection ranged from 1.06 to 1.62 log<sub>10</sub> in the 21-dpv model and from 1.26 to 1.64 log<sub>10</sub> in the 28-dpv model. In summary, we demonstrated that the serological method is useful for predicting the homologous and heterologous protection statuses of vaccinated pigs. |
| first_indexed | 2024-03-08T09:44:39Z |
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| id | doaj.art-661fb91817f545b5851b1b38c0e9542a |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T09:44:39Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-661fb91817f545b5851b1b38c0e9542a2024-01-29T14:25:10ZengMDPI AGVaccines2076-393X2023-12-011211010.3390/vaccines12010010An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in PigsJaejo Kim0Seung Heon Lee1Ha-Hyun Kim2Sung-Ho Shin3Sang-Hyun Park4Jong-Hyeon Park5Choi-Kyu Park6Animal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaAnimal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaAnimal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaAnimal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaAnimal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaAnimal and Plant Quarantine Agency, 177 Hyeoksin 8-ro, Gimcheon City 39660, Gyeongsangbuk-do, Republic of KoreaCollege of Veterinary Medicine & Animal Disease Intervention Center, Kyungpook National University, Daegu 41566, Republic of KoreaTo analyze the relationship between homologous and heterologous serological titers of immunized pigs and their protection statuses against FMD virus challenges, in the present study, the correlation between the virus neutralization titers at 21 and 28 dpv and the protection statuses at 28 dpv against challenge with FMD virus was analyzed using data sets comprising five different combinations of homologous or heterologous challenge experiments in pigs vaccinated with type O (<i>n</i> = 96), A (<i>n</i> = 69), and Asia 1 (<i>n</i> = 74). As a result, the experiments were divided into three groups (21D-1, 21D-2, and 21D-3) in the 21-dpv model and two groups (28D-1 and 28D-2) in the 28-dpv model. Each response curve of groups 21D-1 and 21D-2 in the 21-dpv model was very similar to each curve of groups 28D-1 and 28D-2 in the 28-dpv model, respectively, even though there was an exceptional extra group (21D-3) in the 21-dpv model. The average titers estimating 0.75 probability of protection ranged from 1.06 to 1.62 log<sub>10</sub> in the 21-dpv model and from 1.26 to 1.64 log<sub>10</sub> in the 28-dpv model. In summary, we demonstrated that the serological method is useful for predicting the homologous and heterologous protection statuses of vaccinated pigs.https://www.mdpi.com/2076-393X/12/1/10foot-and-mouth diseasevaccinationindirect potency testvirus neutralization antibodyestimating the protection status |
| spellingShingle | Jaejo Kim Seung Heon Lee Ha-Hyun Kim Sung-Ho Shin Sang-Hyun Park Jong-Hyeon Park Choi-Kyu Park An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs Vaccines foot-and-mouth disease vaccination indirect potency test virus neutralization antibody estimating the protection status |
| title | An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs |
| title_full | An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs |
| title_fullStr | An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs |
| title_full_unstemmed | An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs |
| title_short | An Alternative Serological Measure for Assessing Foot-and-Mouth Disease Vaccine Efficacy against Homologous and Heterologous Viral Challenges in Pigs |
| title_sort | alternative serological measure for assessing foot and mouth disease vaccine efficacy against homologous and heterologous viral challenges in pigs |
| topic | foot-and-mouth disease vaccination indirect potency test virus neutralization antibody estimating the protection status |
| url | https://www.mdpi.com/2076-393X/12/1/10 |
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