Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The inta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/8/2386 |
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| author | Jorge A. Ramírez-Tejero Esther Martínez-Lara M Ángeles Peinado María Luisa del Moral Eva Siles |
| author_facet | Jorge A. Ramírez-Tejero Esther Martínez-Lara M Ángeles Peinado María Luisa del Moral Eva Siles |
| author_sort | Jorge A. Ramírez-Tejero |
| collection | DOAJ |
| description | Fibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritional relevant dose of HT. Our results unveiled that fibroblast from FM show a differential expression in proteins involved in the turnover of extracellular matrix and oxidative metabolism that could explain the inflammatory status of these patients. Moreover, a number of these proteins results normalized by the treatment with HT. In conclusion, our results support that an HT-enriched diet could be highly beneficial in the management of FM. |
| first_indexed | 2024-03-10T17:43:46Z |
| format | Article |
| id | doaj.art-661fc9b34c524184833a1f19dd04d2d3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T17:43:46Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-661fc9b34c524184833a1f19dd04d2d32023-11-20T09:35:57ZengMDPI AGNutrients2072-66432020-08-01128238610.3390/nu12082386Hydroxytyrosol as a Promising Ally in the Treatment of FibromyalgiaJorge A. Ramírez-Tejero0Esther Martínez-Lara1M Ángeles Peinado2María Luisa del Moral3Eva Siles4Department of Experimental Biology, University of Jaén, 23071 Jaén, SpainDepartment of Experimental Biology, University of Jaén, 23071 Jaén, SpainDepartment of Experimental Biology, University of Jaén, 23071 Jaén, SpainDepartment of Experimental Biology, University of Jaén, 23071 Jaén, SpainDepartment of Experimental Biology, University of Jaén, 23071 Jaén, SpainFibromyalgia (FM) is a chronic and highly disabling syndrome, which is still underdiagnosed, with controversial treatment. Although its aetiology is unknown, a number of studies have pointed to the involvement of altered mitochondrial metabolism, increased oxidative stress and inflammation. The intake of extra virgin olive oil, and particularly of one of its phenolic compounds, hydroxytyrosol (HT), has proven to be protective in terms of redox homeostatic balance and the reduction of inflammation. In this context, using a proteomic approach with nanoscale liquid chromatography coupled to tandem mass spectrometry, the present study analysed: (i) Changes in the proteome of dermal fibroblasts from a patient with FM versus a healthy control, and (ii) the effect of the treatment with a nutritional relevant dose of HT. Our results unveiled that fibroblast from FM show a differential expression in proteins involved in the turnover of extracellular matrix and oxidative metabolism that could explain the inflammatory status of these patients. Moreover, a number of these proteins results normalized by the treatment with HT. In conclusion, our results support that an HT-enriched diet could be highly beneficial in the management of FM.https://www.mdpi.com/2072-6643/12/8/2386fibromyalgiahydroxytyrosolextracellular matrixenergy metabolism |
| spellingShingle | Jorge A. Ramírez-Tejero Esther Martínez-Lara M Ángeles Peinado María Luisa del Moral Eva Siles Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia Nutrients fibromyalgia hydroxytyrosol extracellular matrix energy metabolism |
| title | Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |
| title_full | Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |
| title_fullStr | Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |
| title_full_unstemmed | Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |
| title_short | Hydroxytyrosol as a Promising Ally in the Treatment of Fibromyalgia |
| title_sort | hydroxytyrosol as a promising ally in the treatment of fibromyalgia |
| topic | fibromyalgia hydroxytyrosol extracellular matrix energy metabolism |
| url | https://www.mdpi.com/2072-6643/12/8/2386 |
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