Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review
Recently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not si...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/1/21 |
| _version_ | 1797543849936027648 |
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| author | Jongho Kim Chaemyeong Lee Ji Hyun Ryu |
| author_facet | Jongho Kim Chaemyeong Lee Ji Hyun Ryu |
| author_sort | Jongho Kim |
| collection | DOAJ |
| description | Recently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not significantly affect the intrinsic properties of the polymers. An example of a catecholic polymer is catechol-conjugated hyaluronic acid. In general, hyaluronic acid shows excellent biocompatibility and biodegradability; thus, it is used in various medical applications. However, hyaluronic acid alone has poor mechanical and tissue adhesion properties. Catechol modification considerably increases the mechanical and underwater adhesive properties of hyaluronic acid, while maintaining its biocompatibility and biodegradability and enabling its use in several biomedical applications. In this review, we briefly describe the synthesis and characteristics of catechol-modified hyaluronic acid, with a specific focus on catechol-involving reactions. Finally, we discuss the basic concepts and therapeutic effects of catechol-conjugated hyaluronic acid for biomedical applications. |
| first_indexed | 2024-03-10T13:51:31Z |
| format | Article |
| id | doaj.art-66223d2772e641028b02e6249e3bba99 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T13:51:31Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-66223d2772e641028b02e6249e3bba992023-11-21T02:05:22ZengMDPI AGApplied Sciences2076-34172020-12-011112110.3390/app11010021Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini ReviewJongho Kim0Chaemyeong Lee1Ji Hyun Ryu2Carbon Composite Materials Research Center, Institute of Advanced Composite Materials, Korea Institute of Science and Technology (KIST), Wanju, Jeonbuk 55324, KoreaDepartment of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03722, KoreaDepartment of Carbon Convergence Engineering, Wonkwang University, Iksan, Jeonbuk 54538, KoreaRecently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not significantly affect the intrinsic properties of the polymers. An example of a catecholic polymer is catechol-conjugated hyaluronic acid. In general, hyaluronic acid shows excellent biocompatibility and biodegradability; thus, it is used in various medical applications. However, hyaluronic acid alone has poor mechanical and tissue adhesion properties. Catechol modification considerably increases the mechanical and underwater adhesive properties of hyaluronic acid, while maintaining its biocompatibility and biodegradability and enabling its use in several biomedical applications. In this review, we briefly describe the synthesis and characteristics of catechol-modified hyaluronic acid, with a specific focus on catechol-involving reactions. Finally, we discuss the basic concepts and therapeutic effects of catechol-conjugated hyaluronic acid for biomedical applications.https://www.mdpi.com/2076-3417/11/1/21bio-inspiredadhesivehyaluronic acidcatecholdopamine |
| spellingShingle | Jongho Kim Chaemyeong Lee Ji Hyun Ryu Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review Applied Sciences bio-inspired adhesive hyaluronic acid catechol dopamine |
| title | Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review |
| title_full | Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review |
| title_fullStr | Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review |
| title_full_unstemmed | Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review |
| title_short | Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review |
| title_sort | adhesive catechol conjugated hyaluronic acid for biomedical applications a mini review |
| topic | bio-inspired adhesive hyaluronic acid catechol dopamine |
| url | https://www.mdpi.com/2076-3417/11/1/21 |
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