Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride
Polymer microgels, including those based on interpenetrating networks (IPNs), are currently vastly studied, and their practical applications are a matter of thriving research. In this work, we show the perspective for the use of polyelectrolyte IPN microgels either as scavengers or carriers of antis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4394 |
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| author | Elena Yu. Kozhunova Galina A. Komarova Oxana V. Vyshivannaya Irina R. Nasimova Anastasia E. Kuvarina Vera S. Sadykova |
| author_facet | Elena Yu. Kozhunova Galina A. Komarova Oxana V. Vyshivannaya Irina R. Nasimova Anastasia E. Kuvarina Vera S. Sadykova |
| author_sort | Elena Yu. Kozhunova |
| collection | DOAJ |
| description | Polymer microgels, including those based on interpenetrating networks (IPNs), are currently vastly studied, and their practical applications are a matter of thriving research. In this work, we show the perspective for the use of polyelectrolyte IPN microgels either as scavengers or carriers of antiseptic substances. Here, we report that poly-<i>N</i>-isopropylacrylamide/polyacrylic acid IPN microgels can efficiently absorb the common bactericidal and virucidal compound benzalkonium chloride. The particles can form a stable aqueous colloidal suspension or be used as building blocks for soft free-standing films. Both materials showed antiseptic efficacy on the examples of <i>Bacillus subtilis</i> and <i>S. aureus</i>, which was approximately equal to the commercial antibiotic. Such polymer biocides can be used as liquid disinfectants, stable surface coatings, or parts of biomedical devices and can enhance the versatility of the possible practical applications of polymer microgels. |
| first_indexed | 2024-03-09T13:32:09Z |
| format | Article |
| id | doaj.art-6622fb443f9f4924b824fc7601ffd868 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:32:09Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6622fb443f9f4924b824fc7601ffd8682023-11-30T21:16:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238439410.3390/ijms23084394Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium ChlorideElena Yu. Kozhunova0Galina A. Komarova1Oxana V. Vyshivannaya2Irina R. Nasimova3Anastasia E. Kuvarina4Vera S. Sadykova5Faculty of Physics, Lomonosov Moscow State University, Lenin Hills 1, Bld. 2, 119991 Moscow, RussiaFaculty of Physics, Lomonosov Moscow State University, Lenin Hills 1, Bld. 2, 119991 Moscow, RussiaFaculty of Physics, Lomonosov Moscow State University, Lenin Hills 1, Bld. 2, 119991 Moscow, RussiaFaculty of Physics, Lomonosov Moscow State University, Lenin Hills 1, Bld. 2, 119991 Moscow, RussiaGause Institute of New Antibiotics, Bolshaya Pirogovskaya St. 11, 119021 Moscow, RussiaGause Institute of New Antibiotics, Bolshaya Pirogovskaya St. 11, 119021 Moscow, RussiaPolymer microgels, including those based on interpenetrating networks (IPNs), are currently vastly studied, and their practical applications are a matter of thriving research. In this work, we show the perspective for the use of polyelectrolyte IPN microgels either as scavengers or carriers of antiseptic substances. Here, we report that poly-<i>N</i>-isopropylacrylamide/polyacrylic acid IPN microgels can efficiently absorb the common bactericidal and virucidal compound benzalkonium chloride. The particles can form a stable aqueous colloidal suspension or be used as building blocks for soft free-standing films. Both materials showed antiseptic efficacy on the examples of <i>Bacillus subtilis</i> and <i>S. aureus</i>, which was approximately equal to the commercial antibiotic. Such polymer biocides can be used as liquid disinfectants, stable surface coatings, or parts of biomedical devices and can enhance the versatility of the possible practical applications of polymer microgels.https://www.mdpi.com/1422-0067/23/8/4394polymersmicrogelsstimuli-responsive polymersPNIPAAmmacromolecular materialsantibacterial |
| spellingShingle | Elena Yu. Kozhunova Galina A. Komarova Oxana V. Vyshivannaya Irina R. Nasimova Anastasia E. Kuvarina Vera S. Sadykova Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride International Journal of Molecular Sciences polymers microgels stimuli-responsive polymers PNIPAAm macromolecular materials antibacterial |
| title | Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride |
| title_full | Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride |
| title_fullStr | Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride |
| title_full_unstemmed | Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride |
| title_short | Antiseptic Materials on the Base of Polymer Interpenetrating Networks Microgels and Benzalkonium Chloride |
| title_sort | antiseptic materials on the base of polymer interpenetrating networks microgels and benzalkonium chloride |
| topic | polymers microgels stimuli-responsive polymers PNIPAAm macromolecular materials antibacterial |
| url | https://www.mdpi.com/1422-0067/23/8/4394 |
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