Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis
Background The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings. Relatively few studies have been conducted in community settings, but these have consistently shown a high prevalence of mul...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-12-01
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| Series: | Global Health Action |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/16549716.2020.1815272 |
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| author | Nana Adoma Nkansa-Gyamfi Joseph Kazibwe Daouda A. K. Traore Emmanuel Nji |
| author_facet | Nana Adoma Nkansa-Gyamfi Joseph Kazibwe Daouda A. K. Traore Emmanuel Nji |
| author_sort | Nana Adoma Nkansa-Gyamfi |
| collection | DOAJ |
| description | Background The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings. Relatively few studies have been conducted in community settings, but these have consistently shown a high prevalence of multidrug-resistant bacteria in low- and middle-income countries (LMICs). Objectives To provide an appraisal of the evidence on the high prevalence of multidrug-, extensive drug-, and pandrug-resistance in commensal Escherichia coli isolates from human sources in community settings in LMICs. Methods Using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, PubMed, EMBASE, MEDLINE, Web of Science, CINAHL, and Cochrane Library databases were systematically searched with the search string: ‘Enterobacteriaceae’, OR ‘E. coli’, OR ‘Escherichia coli’, AND ‘antibiotic resistance’, OR ‘antimicrobial resistance’, OR ‘drug-resistance’, AND ‘prevalence’, OR ‘incidence’, OR ‘morbidity’, OR ‘odds ratio’, OR ‘risk ratio’, OR ‘confidence interval’, OR ‘p-value’, OR ‘rate’. Data were extracted and proportional meta-analysis was performed using the Freeman–Tukey transformation random effect model. Results The prevalence of multidrug-, extensive drug- and pandrug-resistance were extracted from articles that met our inclusion criteria and pooled together after a systematic screening of 9,369 items. The prevalence of multidrug-resistance was 28% of 14,336 total cases of isolates tested, 95% CI: 23–32. Extensive drug-resistance was 24% of 8,686 total cases of isolates tested, 95% CI: 14–36. Lastly, pandrug-resistance was 5% of 5,670 total cases of isolates tested, 95% CI: 3–8. Conclusion This paper provides an appraisal of the evidence on the high prevalence of multidrug-, extensive drug- and pandrug-resistance by commensal E. coli in community settings in LMICs. Our results call for greater effort to be placed at the community level in the design of new and improved public health policies to counter the global threat of antibiotic-resistant infections and bacteria. |
| first_indexed | 2024-12-21T13:09:52Z |
| format | Article |
| id | doaj.art-66252ac004644c05ad4c17da279ed95a |
| institution | Directory Open Access Journal |
| issn | 1654-9880 |
| language | English |
| last_indexed | 2024-12-21T13:09:52Z |
| publishDate | 2019-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Global Health Action |
| spelling | doaj.art-66252ac004644c05ad4c17da279ed95a2022-12-21T19:02:55ZengTaylor & Francis GroupGlobal Health Action1654-98802019-12-0112S110.1080/16549716.2020.18152721815272Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysisNana Adoma Nkansa-Gyamfi0Joseph Kazibwe1Daouda A. K. Traore2Emmanuel Nji3BioStruct-AfricaImperial College LondonBioStruct-AfricaBioStruct-AfricaBackground The majority of existing studies aimed at investigating the incidence and prevalence of multidrug-resistance by bacteria have been performed in healthcare settings. Relatively few studies have been conducted in community settings, but these have consistently shown a high prevalence of multidrug-resistant bacteria in low- and middle-income countries (LMICs). Objectives To provide an appraisal of the evidence on the high prevalence of multidrug-, extensive drug-, and pandrug-resistance in commensal Escherichia coli isolates from human sources in community settings in LMICs. Methods Using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, PubMed, EMBASE, MEDLINE, Web of Science, CINAHL, and Cochrane Library databases were systematically searched with the search string: ‘Enterobacteriaceae’, OR ‘E. coli’, OR ‘Escherichia coli’, AND ‘antibiotic resistance’, OR ‘antimicrobial resistance’, OR ‘drug-resistance’, AND ‘prevalence’, OR ‘incidence’, OR ‘morbidity’, OR ‘odds ratio’, OR ‘risk ratio’, OR ‘confidence interval’, OR ‘p-value’, OR ‘rate’. Data were extracted and proportional meta-analysis was performed using the Freeman–Tukey transformation random effect model. Results The prevalence of multidrug-, extensive drug- and pandrug-resistance were extracted from articles that met our inclusion criteria and pooled together after a systematic screening of 9,369 items. The prevalence of multidrug-resistance was 28% of 14,336 total cases of isolates tested, 95% CI: 23–32. Extensive drug-resistance was 24% of 8,686 total cases of isolates tested, 95% CI: 14–36. Lastly, pandrug-resistance was 5% of 5,670 total cases of isolates tested, 95% CI: 3–8. Conclusion This paper provides an appraisal of the evidence on the high prevalence of multidrug-, extensive drug- and pandrug-resistance by commensal E. coli in community settings in LMICs. Our results call for greater effort to be placed at the community level in the design of new and improved public health policies to counter the global threat of antibiotic-resistant infections and bacteria.http://dx.doi.org/10.1080/16549716.2020.1815272antimicrobial resistance |
| spellingShingle | Nana Adoma Nkansa-Gyamfi Joseph Kazibwe Daouda A. K. Traore Emmanuel Nji Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis Global Health Action antimicrobial resistance |
| title | Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis |
| title_full | Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis |
| title_fullStr | Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis |
| title_short | Prevalence of multidrug-, extensive drug-, and pandrug-resistant commensal Escherichia coli isolated from healthy humans in community settings in low- and middle-income countries: a systematic review and meta-analysis |
| title_sort | prevalence of multidrug extensive drug and pandrug resistant commensal escherichia coli isolated from healthy humans in community settings in low and middle income countries a systematic review and meta analysis |
| topic | antimicrobial resistance |
| url | http://dx.doi.org/10.1080/16549716.2020.1815272 |
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